A one-pot procedure was developed for the synthesis of novel 3-[amino(methoxy)methylene]-2-oxo-3,4-dihydro-2H-chromen-4-yl)-3-cyanoacetamides and chromeno[3,4-c]pyridine-1-carbonitriles from the reaction of 2-oxo-2H-chromene-3-carbonitriles and cyanoacetamides. These chromene derivatives were identified as new scaffolds for adenosine receptors and the hits 3a, 3c, 5a, and 5b were found.

A series of 1,3-benzoxazole-4-carbonitriles was synthesized and evaluated for its antifungal activity, solubility, and metabolic stability. Among those compounds, 4-cyano-N,N,5-trimethyl-7-[(3S)-3-methyl-3-(methylamino)pyrrolidin-1-yl]-6-phenyl-1,3-benzoxazole-2-carboxamide (16b) exhibited potent in vitro activity against Candida species, higher water solubility, and improved metabolic stabilit...

A series of new 3-Aryl-4-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitriles (1) were screened in vitro for their antibacterial and antifungal activities against four different organisms. The minimal inhibitory concentration (MIC’s) was determined against each organism. The compounds were tested for their antioxidant activity and reducing power ability. The effect of substitution...

There has been considerable interest in the pro­ ducts of the reaction of 2 ,2 '-bipyridine with di­ bromoalkanes. The bridged diquaternary salt (1) from 2 ,2 '-bipyridine and 1 ,2 -dibromoethane is the well-known herbicide diquat dibromide [1]. Similar bridged salts are obtained with 1,3-dibromopropane and 1,4-dibromobutane [2] but reaction of 2,2'-bipyridine with 1,5-dibromopentane gives inst...

A 2,2'-bipyridine-appended ferrocene rotor, 1,1'-di(5-yl-ethynyl-2,2'-bipyridine)ferrocene, can be switched from a folded/stacked (syn) conformation to an extended/unstacked (anti) conformation by the addition of [Cu(CH3CN)4](PF6) and 6,6'-dimesityl-2,2'-bipyridine. This extension and contraction process was completely reversible and could be triggered either chemically or electrochemically.

H etero-Diels-Alder Reaction, a,/?-Unsaturated Ketones, Styrenes Cycloadditions of 3-aryl-2-benzoyl-2-propenenitriles la,b to styrene (2a) and its methylor methoxy-substituted derivatives 2b-d proceed regioand diastereoselectively yielding cis and trans diastereoisomers of 2,4,6-triaryl-3,4-dihydro-2//-pyran-5-carbonitriles 3 and 4 in 59-72% yield. Cycloadducts cis-3 were the major products. Re...

The synthesis and characterization of eight new bis-cyclometalated compounds [M(ptpy)2(N^N)]PF6 (ptpy=2-(p-tolyl)pyridinato; N^N=5-chloro-1,10-phenanthroline: M=Rh, 1; M=Ir, 2); N^N=5-methyl-1,10-phenanthroline: 3; 4; N^N=4,4’-diphenyl-2,2’-bipyridine: 5; 6; N^N=4,4’-diamino-2,2’-bipyridine: 7; 8) are described. All were characterized by spectroscopic means. Additionally, the molecular structur...

Amphiphilic ligands 4,4'-bis(1-adamantyl-aminocarbonyl)-2,2'-bipyridine (L(1)), 4,4'-bis[5-[N-[2-(3beta-cholest-5-en-3-ylcarbamate-N-yl)ethyl]aminocarbonyl]]-2,2'-bipyridine (L(2)), 4,4'-bis[5-[N-[2-(3beta-cholest-5-en-3-ylcarbamate-N-yl)propyl]aminocarbonyl]]-2,2'-bipyridine (L(3)), and 4,4'-bis(dodecan-12-ol)-2,2'-bipyridine (L(4)) and their heteroleptic ruthenium(II) complexes of the type [R...

With the aim of improving the photoconversion efficiencies of heteroleptic [Cu(Lanchor)(Lancillary)](+) dyes in n-type dye-sensitized solar cells (DSCs), the previously favoured anchor ((6,6'-dimethyl-[2,2'-bipyridine]-4,4'-diyl)bis(4,1-phenylene))bis(phosphonic acid) (1) has been replaced by analogues 2 and 3 containing 2-thienyl spacers between the 2,2'-bipyridine metal-binding domain and the...