نتایج جستجو برای: 396
تعداد نتایج: 3437 فیلتر نتایج به سال:
Many different aberrations in the Anaplastic Lymphoma Kinase (ALK) were found to be oncogenic drivers in several cancers including neuroblastoma (NB), therefore ALK is now considered a critical player in NB oncogenesis and a promising therapeutic target. The ALK-inhibitor crizotinib has a limited activity against the various ALK mutations identified in NB patients. We tested: the activity of th...
Abstract Background The exploration of genomic alterations in Chinese colorectal liver metastasis (CRLM) is limited, and corresponding genetic biomarkers for patient’s perioperative management are still lacking. This study aims to understand genome diversification complexity that developed CRLM. Methods A custom-designed IDT capture panel including 620 genes was performed the CRLM cohort, which...
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Aberrant forms of the anaplastic lymphoma kinase (ALK) have been implicated in the pathogenesis of multiple human cancers, where ALK represents a rational therapeutic target in these settings. In this study, we report the identification and biological characterization of X-376 and X-396, two potent and highly specific ALK small molecule tyrosine kinase inhibitors (TKIs). In Ambit kinome screens...
Perspectives and Summary ........................................................................................ 395 Structural Models for DNA ...................................................................................... 396 Origins of polynucleotide models ... ........................................................................... 396 Terminology and conventions ....................
Background: Pulsed-field gel electrophoresis (PFGE) typing has been recognized by several groups as a Abstract relatively simple and quick method for genotyping of Campylobacter jejuni (C. jejuni). The present study was carried out to determine the genetic variations among clinical isolates of C. jejuni from Greece and to establish a database, which could be used for future epidemiological and ...
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