111 Received: Revised: Accepted: October 29, 2014 November 30, 2014 December 3, 2014 Corresponding Author: Duk-Kyung Kim, Division of Cardiology, Department of Medicine, Heart, Stroke and Vascular Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-Gu, Seoul 135-710, Korea Tel: +82-2-3410-3419, Fax: +82-2-3410-3849, E-mail: [email protected]...

The ASO field is an emerging area of drug development that targets the disease source at RNA level, offering a promising alternative to therapies targeting downstream processes. SpliSense developing SPL84, inhaled for treatment CF patients carrying 3849 +10 kb C->T mutation. In order move into clinic, we performed full battery preclinical safety and toxicology studies with SPL84. vitro in silic...

Cystic fibrosis (CF, OMIM 219700) is one of the most common severe hereditary diseases occurring in white populations. It is characterised by considerable heterogeneity in the mutational spectrum and a diverse phenotypic presentation, which justifies extensive studies on the correlation between the cystic fibrosis transmembrane regulator (CFTR) genotype and the CF phenotype. Genotype-phenotype ...

Preimplantation genetic diagnosis (PGD) for monogenic diseases is widely applied, allowing the transfer to the uterus of healthy embryos. PGD is also employed for the detection of chromosome abnormalities for couples at high risk of producing aneuploid embryos, such as advanced maternal (>35 years). A significant number of patients requesting PGD for monogenic diseases are also indicated for ch...

Image analysis and retrieval may need to consider several types of visual features and spatial information between them (e.g. different points of views of an image). This paper presents a novel approach that exploits an extension of the language modeling approach from information retrieval to the problem of graph-based image retrieval and categorization. Such versatile graph model is needed to ...

Common lymphatic endothelial and vascular endothelial receptor-1 (CLEVER-1; also known as stabilin-1 or FEEL-1) is a large multifunctional glycoprotein implicated in scavenging, angiogenesis, and cell adhesion. Here we studied the function of human CLEVER-1 in leukocyte trafficking. Lymphatic vessels expressed CLEVER-1 constitutively in skin in vivo, whereas on vascular endothelium it appeared ...

In this paper, we construct an entity recognition and linking system using Chinese Wikipedia and knowledge base. We utilize refined filter rules in entity recognition module, and then generate candidate entities by search engine and attributes in Wikipedia article pages. In entity linking module, we propose a hybrid entity re-ranking method combined with three features: textual and semantic mat...

The effects of acute and subacute toxicity of 1,8-cineole in Kunming mice were studied. After acute oral administration, the LD50 value (95% CL) was 3849 mg/kg (3488.8~4247.1 mg/kg). In the subacute toxicity study, there were no significant differences in body weight and relative organ weight between the control group and 1,8-cineole treatment groups. The histopathological examinations showed t...