Fabrication of precisely designed active biomaterials is of great interest in many areas of bionanotechnology including regenerative medicine, drug screening, and biosensors. Microand nanometre scale defined patterns have been developed which can control the spacing and density of signaling molecules through top-down microfabrication approaches, such as photolithography, e-beam lithography, and...

Cytosolic sulfotransferases (SULTs) catalyze the sulfate conjugation of a myriad of endogenous and xenobiotic substrates. Among the 13 human SULTs, little is known regarding regulation of the SULT1C subfamily. We evaluated the effects of a panel of transcription factor activators on levels of SULT1C mRNA (1C2 and 1C3) and protein (1C2) in LS180 colorectal adenocarcinoma cells. Treatment with 3-...

background: cobalamin deficiency and peripheral neuropathy (pn) are commonly seen in hiv-infected adults. the level of urine methylmalonic acid (umma), a reliable indicator of tissue cobalamin status, was determined in hiv infected subjects with and without pn to establish this association. methods: one hundred and ninety-eight (198) consenting hiv infected subjects with and without pn were rec...

BACKGROUND/AIMS Colonic peristalsis is mainly regulated via intrinsic neurons in guinea pigs. However, autonomic regulation of colonic motility is poorly understood. We explored a guinea pig model for the study of extrinsic nerve effects on the distal colon. METHODS Guinea pigs were sacrificed, their distal colons isolated, preserving pelvic nerves (PN) and inferior mesenteric ganglia (IMG), ...

Leaf gas exchange was assessed in Avicennia germinans L. grown under different NaCl concentrations (0-40 per thousand), after salt-relief, and then during drought. Stomatal conductance (gs) and net photosynthetic rate (Pn) decreased with increasing NaCl concentration, and intrinsic water use efficiency (Pn / gs) increased. Under desalinization Pn / gs declined. Thus, gs did not change in plants...

Four new complexes of the type [LCo ((DO)(DOH) pn) Cl] PF , where (DO) (DOH) pn = N , N '- propanediylbis (2, 3-butanedione2-imine3-oxirne)a nd L =morpholine (mrpln) (I), benzylamine (bzlan) (II), piperidine (pprdn)(III) and pyrrolidine (prldn) (IV) have been synthesized and characterized by elemental analyses and spectroscopic methods. Approximate values of the angular-overlap parameter, ?, ...

The reactions pn → dω and pn → dφ are studied within a relativistic meson-exchange model of hadronic interactions. Predictions for the total cross sections and for the angular distributions of the vector mesons are presented. The resulting cross sections near threshold are around 10-30 µb for pn → dω and 200-250 nb for pn → dφ. A moderate deviation of the cross section ratio σ pn→dφ /σ pn→dω fr...

The human tyrosinase gene codes for two distinct antigens that are recognized by HLA-A*0201-restricted CTLs. For one of them, tyrosinase peptide 368-376, the sequence identified by mass spectrometry in melanoma cell eluates differs from the gene-encoded sequence as a result of posttranslational modification of amino acid residue 370 (asparagine to aspartic acid). Here, we used fluorescent tetra...