The pharmacokinetics and safety of BILR 355 following oral repeated dosing coadministered with low doses of ritonavir (RTV) were investigated in 12 cohorts of healthy male volunteers with a ratio of 6 to 2 for BILR 355 versus the placebo. BILR 355 was given once a day (QD) coadministered with 100 mg RTV (BILR 355/r) at 5 to 50 mg in a polyethylene glycol solution or at 50 to 250 mg as tablets. ...

6. Specific goals for the course a. Specific outcomes of instruction: 1. Prove theorems in discrete math by induction, contradiction, or cases 2. Analyze, design, and manipulate finite state acceptors 3. Design and manipulate regular expressions 4. Prove languages not regular or context-free 5. Design and analyze context-free grammars and push-down automata 6. Analyze and simulate a Turing mach...

The topoisomerase I inhibitor GL147211C [7-[(4-methylpiperazino)methyl]-10,11-(ethylenedioxy)-(20S)-campto thecin trifluoroacetate], a camptothecin analogue, has significant activity in tumor cell cytotoxicity assays in vitro and antitumor activity in both animal tumor models and human patients. Its toxicity is significant, however, effectively limiting the amount of drug that can be administer...

11-Ethyl-5,11-dihydro-5-methyl-8-[2-[(1-oxido-4-quinolinyl)oxy] ethyl]-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (BILR 355) is an inhibitor of the human immunodeficiency virus-1. BILR 355 exhibited a nonlinear pharmacokinetic profile and low exposure after oral administration to humans. This article describes the in vitro metabolism of BILR 355, which is correlated with the in vivo nonlinea...

We discuss ROSAT, ASCA, BeppoSAX and optical observations of the young active star Gl 355. During the ROSAT observation a strong flare was detected with a peak flux more than an order of magnitude larger than the quiescent level. Spectral analysis of the data allows us to study the temperature and emission measure distribution, and the coronal metal abundance, for the quiescent phase and, in th...

1Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, 60-355 Poznan, Przybyszewskiego str. 49, Poland 2Neuroimmunological Unit, Polish Academy of Sciences, 60-355 Poznan, Przybyszewskiego str. 49, Poland 3Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Przybyszewskiego str. 49, Poland 4Department of Clinical Biochemistry and Labo...

BACKGROUND We wished to determine the safety and anti-human immunodeficiency virus (HIV) type 1 activity of single doses of TNX-355, a humanized IgG4 anti-CD4 monoclonal antibody with potent activity against HIV-1 in vitro, in HIV-infected subjects. METHODS Sequential cohorts of 6 HIV-1-infected subjects each received infusions of TNX-355. Data included plasma HIV-1 RNA level, CD4+ T cell cou...

Ritonavir (RTV) was used as a boosting agent to increase the clinical exposure of 11-ethyl-5,11-dihydro-5-methyl-8-[2-[(1-oxido-4-quinolinyl)oxy]ethyl]-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (BILR 355), an inhibitor of the human immunodeficiency virus, by inhibiting the CYP3A-mediated metabolism of BILR 355. However, although the levels of BILR 355 increased upon concomitant administrati...

Linear depolarization ratios in clean air ranges were measured with POLIS-6 at 355 and 532 nm. The mean deviation from the theoretical values, including the rotational Raman lines within the filter bandwidths, amounts to 0.0005 at 355 nm and to 0.0012 at 532 nm. The mean uncertainty of the measured linear depolarization ratio of clean air is about 0.0005 at 355 nm and about 0.0006 at 532 nm.