BACKGROUND S-phase kinase-associated protein 2 (Skp2) takes great part in the development of multiple tumors. However, the post-transcriptional modulation mechanism of Skp2 remains unclear. Here, we present a new regulatory microRNA of Skp2, miR-339, which directly targets Skp2 to inhibit cell proliferation in lung cancer. METHODS The expression of miR-339 or Skp2 in lung cancer samples was t...

339 ADICCIONES, 2012 · VOL. 24 NÚM. 4 · PÁGS. 339-346 Conocer qué factores predicen el consumo de psicoestimulantes en jóvenes es importante para el diseño de programas preventivos y para identificar a los jóvenes que tienen una mayor probabilidad de consumir y así evitar que aparezcan los problemas derivados de dicho consumo. El objetivo de este estudio fue analizar la relación entre la dispon...

Osteoporosis, a metabolic skeletal disease characterised by decreased bone mass and increased fracture risk, is a growing public health problem. Among the various risk factors for osteoporosis, calcium and vitamin D have well-established protective roles, but it is likely that other nutritional factors are also implicated. This review will explore the emerging evidence supporting a role for cer...

MicroRNAs (miRNAs) serve important roles in regulating cancer cell proliferation and metastasis. The same hairpin RNA structure may produce mature products from each strand, termed miR-5p and miR-3p, which can bind different mRNAs. Previously, the present authors reported that miR-339-5p could inhibit cell proliferation and migration by targeting the 3'-untranslated region (3'-UTR) of PRL-1 mRN...

د ماعتملا فعاضملا يددر تلا مي سقتلا ما ظنل أ طخلا لد عم بسح ءادلاا (OFDM) يلضافت ريف شتل مدختسملا عو ن 16 يمجنلا د ماعتم يراد قم نيمضتب (QAM) نماز تم يلضافت فشاآو هيسواآ هفاضم ءاضيب ءاضوض تاذ ل قن ةا نقو ا ع يزوتل نيراسمب توفخ تاذ ىرخاو حطسم ددرت تاذ ةانقو صخلملا : ت نا يف لمعتسأٌ د ماعتملا فعاضملا يددر تلا مي سقتلا مسأب فورعملا ةددعتملا ةلماحلا تاددرتلا وذ لاسرلاا ةينق تانيتسلا دقع ) 1960's...

Dietary strategies that can help reduce hunger and promote fullness are beneficial for weight control, since these are major limiting factors for success. High-protein (HP) diets, specifically those that maintain the absolute number of grams ingested, while reducing energy, are a popular strategy for weight loss (WL) due to the effects of protein-induced satiety to control hunger. Nonetheless, ...

Exogenous bone morphogenetic proteins (Bmp) are well known to induce ectopic bone formation, but the physiological effect of Bmp signaling on normal bone is not completely understood. By deleting the receptor Bmpr1a in osteoblast lineage cells with Dmp1-Cre, we observed a dramatic increase in trabecular bone mass in postnatal mice, which was due to a marked increase in osteoblast number that wa...

تركز هذه الدارسة على طقوس التعبد التي يؤديها الفرد العراقي القديم في عصور قديمة وبشكل خاص العصر البابلي وتجسدت الطقوس بمشاهد فنية من واقع المجتمع والتركيز النحت البارز بشكل للدراسة حالات لان يعد الأعمال الفنية النادرة ، وكذلك اعتمادهم نمط محدد وهذا يظهر واضح وايضاً الاختام يدل أًن المتعبدين يؤدون نفس التعبدية تقربهم الآلهة.