The c-Jun N-terminal protein kinase (JNK) and its two direct activators, namely the mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) andMKK7, constitute a signaling node frequently mutated in human pancreatic ductal adenocarcinoma (PDAC). Here we demonstrate the cooperative interaction of endogenous expression of Kras with loss-of-function mutations in mkk4 or both, mkk4 and mkk7 genes i...

This study assessed the dimensionality of the Empathy Quotient (EQ) using two statistical approaches: Rasch and Confirmatory Factor Analysis (CFA). Participants included N = 658 with an autism spectrum condition diagnosis (ASC), N = 1375 family members of this group, and N = 3344 typical controls. Data were applied to the Rasch model (Rating Scale) using WINSTEPS. The Rasch model explained 83% ...

To establish whether serum bilirubin levels vary in healthy term neonates according to seasonal variations and meteorological factors, we retrospectively studied 3344 born between 2013 2018. Total (TSB) were measured on the fourth day after birth. The monthly TSB clinical effects assessed. In enrolled neonates, median level was 195 µmol/L. peaked December lowest July, but variation not statisti...

Abstract The effects of various material compositions and reservoir environments on the ultimate strength swelling kinetics a commercial preformed particle gel (PPG) have been investigated. This study used different ratios acrylamide acrylic acid copolymers with specific crosslinker concentration. Results indicated that increasing proportion enhances PPGs’ ability to swell but weakens their net...

AGE RELATED LIPID OXIDATION IN HUMAN LENS MEMBRANES BY INFRARED SPECTROSCOPY. Borchman D. Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville Kentucky, 40202, USA. To measure primaty and secondary products of lipid Purnose oxidation with age in human lens membranes. Lipid oxidation is believed to contribute to a number of senescent diseases including cataract. ...

Since the entire world's sericulture, to achieve maximum heterosis is based on feeding of hybrids only first generation, therefore, operations for preparation pure are particular importance. In Uzbekistan, Sericulture Research Institute has developed new biotechnologies specifically solve this problem, and genetically modified breeds parthenogenetic clones have been created their basis. The unf...

Influence of predictive information on responses of tonically active neurons in the monkey striatum. J. Neurophysiol. 80: 3341-3344, 1998. We investigated how the expectation of a signal of behavioral significance influences the activity of tonically active neurons in the striatum of two monkeys performing a simple reaction time task under two conditions, an uncued condition in which the trigge...