BACKGROUND Dysregulation of miR-675 has been found in a variety of solid tumors. MiR-675 has been suggested as having both oncogenic and tumor suppression properties in cancer. However, there is no evidence whether miR-675 is involved in breast cancer. The objective of this study was to evaluate the expression status of miR-675 and its clinical relevance in breast cancer patients. METHODS The...

Article history: Received 31 October 2016 Accepted 1 November 2016 Available online 9 November 2016 (both miR-675-5p and miR-675-3p) expression in clinical samples. MiR-675-5p was undetectable in TCGA samples, while miR-675-3p expression correlated with H19 levels, but was no predictor either for overall or disease-free survival. At least in their model system that Calin and coworkers used, H19...

H19 non-coding RNA downregulation stimulates melanogenesis in melasma patients. However, its mechanism is unclear. In this study, the potential role of a H19 microRNA, miR-675, in melanogenesis was examined. Real-time PCR using cultured normal human skin keratinocytes, melanocytes, and fibroblasts with or without H19 knockdown showed accompanying changes between expression levels of H19 and tho...

Analytical sociology is a middle-range approach to sociological theorizing which seeks to develop precise and realistic action-based explanations of various social phenomena. At the heart of the analytical approach is the idea that acceptable explanations must detail the mechanisms through which the phenomena to be explained were brought about. In this article I discuss the most important eleme...

Trichinella spiralis nudix hydrolase (TsNd) gene encoding a 46 kDa protein was expressed in Escherichia coli and the potential of recombinant TsNd protein (rTsNd) as an antigen for the serodiagnosis of trichinellosis was investigated by ELISA and compared with those of ELISA with T. spiralis muscle larval excretory–secretory (ES) antigens. The sensitivity of both ELISA was 100% (30/30), for the...

The mouse Lyt-1, Lyt-2, and Lyt-3 lymphocyte surface antigens have been used for some years now as immunogenet ic markers whose selective expression distinguishes maturat ional and functional T cell subpopulations (1, 2). Lyt-2 and Lyt-3, for example, are selectively expressed on cytotoxic and suppressor T cells but are not found on helper T cells (3, 4). Similarly, cytotoxic depletion studies ...

AIMS The H19 lncRNA, a highly abundant and conserved imprinted gene, has been implicated in many essential biological processes and diseases. However, the function of H19 in the heart remains unknown. In this study, we investigated the function and underlying mechanism of H19 in regulating cardiomyocyte hypertrophy. METHODS AND RESULTS We first detected the expression of H19 and its encoded m...

MicroRNA-675 (miR-675) plays an important role in tumorigenesis and development of various cancers. However, the expression status and the prognostic implication of miR-675 in acute myeloid leukemia (AML) remain largely elusive. In this study, real-time quantitative PCR was carried out to examine miR-675 level in 114 de novo AML patients and 26 controls. The level of miR-675 expression was sign...

To be able to build acoustic models for children, that can be used in spoken dialogue systems, speech data has to be collected. Commercial recognizers available for Swedish are trained on adult speech, which makes them less suitable for children's computer-directed speech. This paper describes some experiments with on-the-fly voice transformation of children's speech. Two transformation methods...

H19 RNA has been characterized as an oncogenic long non-coding RNA (lncRNA) in breast and colon cancer. However, the role and function of lncRNA H19 in glioma development remain unclear. In this study, we identified that H19/miR-675 signaling was critical for glioma progression. By analyzing glioma gene expression data sets, we found increased H19 in high grade gliomas. H19 depletion via siRNA ...