Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare and severe genetic skin disease responsible for blistering of the mucosa after minor trauma. RDEB caused by wide variety mutations in COL7A1 encoding type VII collagen, major component anchoring fibrils which form key attachment structures dermal-epidermal adhesion. In our study, we investigated therapeutic potential combined CRISPR/Ca...

Parts of the sandy littoral sediment of a Precambrian shield lake (Lake 302s) were intermittently covered with a layer of flocculent organic-rich material l-20 mm thick. Sandy sediments with flocculent surface sediment had higher rates of respiration (31-105%) and photosynthesis (37224%) than those without. Densities of invertebrate macrofauna were 10 times higher in the flocculent surface sedi...