The Computer Systems Laboratory (CSL), National Institute of Standards and Technology, sponsored the sixteenth North American ISDN Users' Forum (NIUF) at its Gaithersburg, Maryland site on October 26-30, 1992. About 250 users, implementors, and service providers of ISDN technology attended the meeting. CSL collaborated with industry in 1988 to establish the NIUF to ensure that emerging ISDN app...

Combination of lactam antibiotic with lactamase inhibitor has been proven to overcome resistance caused by lactamase production. An evaluation to the MIC of some lactam antibiotics to b-lactamase producing isolates will be reported. A.anitratus, E.coli, K.pneumoniae, Proteus sp, Pseudomonas sp, S.aureus, S.epidermidis, S.pneumoniae, S.viridans, and hemolytic Streptococcus, were challe...

A “role set” is the set of classes in a class hierarchy where an object may reside simultaneously. A “migration pattern” is a sequence of role sets that an object can migrate through. We define a “migration inventory”, which is a set of migration patterns, as a dynamic integrity constraint on object migration. We consider three update languages: SL which has five operators, CSL+ which extends S...

BACKGROUND CSL (CBF1/RBP-Jκ/Suppressor of Hairless/LAG-1) transcription factors are the effector components of the Notch receptor signalling pathway, which is critical for metazoan development. The metazoan CSL proteins (class M) can also function in a Notch-independent manner. Recently, two novel classes of CSL proteins, designated F1 and F2, have been identified in fungi. The role of the fung...

Notch signaling is an important regulator of stem cell differentiation. All canonical Notch signaling is transmitted through the DNA-binding protein CSL, and hyperactivated Notch signaling is associated with tumor development; thus it may be anticipated that CSL deficiency should reduce tumor growth. In contrast, we report that genetic removal of CSL in breast tumor cells caused accelerated gro...

Condensed fermented corn extractives (liquid steep liquor) was assessed as an alternative to organic acids in broiler chicken. Day-old Ross 308 chicken (n = 180) were allocated into six treatments (basal diet with no supplement, basal supplemented 1 and 2 cc/kg liquid liquor (CSL) or formic acid along probiotic (1 × 108 CFU/g, Lactobacillus acidophilus, casei) a completely randomised design fiv...

Cryptosporidiosis, caused by the apicomplexan parasite Cryptosporidium parvum, has become a well-recognized diarrheal disease of humans and other mammals throughout the world. No approved parasite-specific drugs, vaccines, or immunotherapies for control of the disease are currently available, although passive immunization with C. parvum-specific antibodies has some efficacy in immunocompromised...

Since Kaposi's sarcoma associated herpesvirus (KSHV) establishes a persistent infection in human B cells, B cells are a critical compartment for viral pathogenesis. RTA, the replication and transcription activator of KSHV, can either directly bind to DNA or use cellular DNA binding factors including CBF1/CSL as DNA adaptors. In addition, the viral factors LANA1 and vIRF4 are known to bind to CB...