Background: The aim of the present study was to investigate the in vitro effects of mercury (Hg+2), lead (Pb+2), silver (Ag+2), tin (Sn+2), bismuth (Bi+3) and indium (In+3) ions on sperm creatine kinase. Methods: creatine kinase was isolated from human sperm homogenates after chromatography on a DEAE cellulose column. Results: At 60 µg ml-1 metal concentration, 70% of the creatine kinase activi...

JAK3 is expressed in 12 normal human tissues (bone marrow, spleen, thymus, brain, spinal cord, heart, skeletal muscle, liver, pancreas, prostate, kidney, and lung). JAK3S is more commonly seen in hematopoietic cells, whereas JAK3B and JAK3M are detected in cells of hematopoietic or epithelial origin. Localisation Intracellular, membrane-associated through association with interleukin (IL) recep...

To study the autophagy and mechanism of phosphatidylinositol-3-kinase/protein kinase B/mammalian target rapamycin signaling pathway in directional differentiation mesenchymal stem cells to provide basic research results for its application medical field is main objective study. The lung bone marrow mice were used as experimental materials. materials divided into five groups according settings n...

background: the aim of the present study was to investigate the in vitro effects of mercury (hg+2), lead (pb+2), silver (ag+2), tin (sn+2), bismuth (bi+3) and indium (in+3) ions on sperm creatine kinase. methods: creatine kinase was isolated from human sperm homogenates after chromatography on a deae cellulose column. results: at 60 µg ml-1 metal concentration, 70% of the creatine kinase activi...

background: osteosarcoma is a malignant tumor with high mortality but effective therapy has not yet been developed. berberine, an isoquinoline alkaloid component in several chinese herbs including huanglian, has been shown to induce growth inhibition and the apoptosis of certain cancer cells. the aim of this study was to determine the role of berberine on human osteosarcoma cell lines u2os and ...