Transesterification, one of the most effective methods for ester synthesis, is usually conducted under acid or basicconditions. Although quite a few methods have been reported for transesterification, they are not general as far asp-ketoesters are concerned. Some of these methods used toxic, expensive reagents and in relatives large amount. Inthis research, transesterification reaction six type...

The proton catalyzed reaction of methyldiazoacetate and benzaldehyde resulting in the formation of b-ketoesters and 3-hydroxyacrylates has been investigated by means of DFT/B3LYP calculations. Experimentally this reaction is performed using HBF4 Et2O as the catalyst and CH2Cl2 as the solvent. Several mechanistic pathways involving 1,2-migration of phenyl-, H-, and OH-substituents have been cons...

Abstract Selective syntheses of coumarin and benzofuran derivatives were achieved via HClO4-mediated intermolecular annulation using phenols α-methoxy-β-ketoesters. Coumarins are formed under dehydrated conditions, whereas benzofurans in the presence water. In synthetic process benzofurans, α-methoxy-β-ketoesters converted into α-methoxyacetophenones, methoxy group is an important element annul...

N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.

transesterification, one of the most effective methods for ester synthesis, is usually conducted under acid or basicconditions. although quite a few methods have been reported for transesterification, they are not general as far asp-ketoesters are concerned. some of these methods used toxic, expensive reagents and in relatives large amount. inthis research, transesterification reaction six type...

A gene encoding an NADH-dependent short-chain dehydrogenase/reductase (gox2036) from Gluconobacter oxydans 621H was cloned and heterogeneously expressed in Escherichia coli. The protein (Gox2036) was purified to homogeneity and biochemically characterized. Gox2036 was a homotetramer with a subunit size of approximately 28 kDa. Gox2036 had a strict requirement for NAD⁺/NADH as the cofactor. Gox2...

Efficient synthesis of fluorinated organic compounds, which plays an important role in the research of biological and medicinal chemistry, and material science, is now becoming one of the most dynamic aspects of modern organic chemistry. Among several strategies for this purpose, late-stage fluoromethylation using easy-to-handle reagents under mild conditions is principally advantageous for the...

The synthesis of spirocyclic amide acetals (33–93 %) has been achieved through Ru(II)-catalyzed condensations N-carbamate protected pyrrolidinones with metal carbenes derived from α-diazo-β-ketoesters. Thanks to the mildness diazo decomposition conditions induced by a 1 : combination [CpRu(MeCN)3][BArF] and 1,10-phenanthroline, formation sensitive products is possible. Full characterization thi...

We discovered a highly reactive λ(3)-hypervalent iodane species using an inorganic/organic base for the unorthodox synthesis of amides and ketoesters through grafting terminal alkynes. In contrast to the metal-catalyzed dehydrative approaches the in situ generated nonmetallic reagent efficiently created C-N/C-O and C[double bond, length as m-dash]O bonds with amines/alkynes and water at rt.

A highly robust and productive self-sufficient heterogeneous biocatalysts to asymmetrically reduce β-ketoesters.