The hepatocyte growth factor receptor (HGFR or c-Met) is a driver of multiple cancer subtypes. While there are several c-Met inhibitors in development, few have been approved for clinical use, warranting the need for continued research and development of c-Met targeting therapeutic modalities. The research presented here demonstrates a particular class of compounds known as isothiocyanatostilbe...

A highly efficient and simple method for the preparation of α,α´-bis(arylidene)cycloalkanones under solvent-free conditions has been developed. The crossed-aldol condensation of cycloalkanones (1 eq.) with arylaldehydes (2 eq.) in the presence of 2.5 mol% of ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate {[Dsim]HSO4} afforded the title compounds in high yields and short reaction ...

Aqueous solutions of tetrabutylphosphonium trifluoroacetate, [P4444]CF3COO, exhibit a liquid-liquid phase transition with a lower critical solution temperature. Herein, we characterized the constituent ions, [P4444](+) and CF3COO(-), in terms of their effects on the molecular organization of H2O on the basis of 1-propanol probing methodology devised by Koga et al. The resulting characterization...

216 words Introduction: 750 words Discussion: 1391 words Non-standard abbreviations: mAChR, muscarinic cholinergic receptor; DIDS, 4,4’ diisothiocyanatostilbene-2,2’-disulfonic acid; NPPB, 5-nitro-2-(3-phenylpropylamino) benzoic acid; Oxo-M, oxotremorine-M; DMEM, Dulbecco’s modified Eagle’s medium; 4DAMP, 4-diphenylacetoxy-N-methylpiperidine methiodide; AF-DX 116, 11-[[2[(diethylamino)methyl]-1...

Mechanistic studies of a palladium-mediated decarboxylative olefination of arene carboxylic acids are presented, providing spectroscopic and, in two instances, crystallographic evidence for intermediates in a proposed stepwise process. Sequentially, the proposed pathway involves carboxyl exchange between palladium(II) bis(trifluoroacetate) and an arene carboxylic acid substrate, rate-determinin...

The syntheses and characterization of four new hybrid coordination networks based on lanthanide ions (Ln = Nd, Sm) and 1,3-carboxymethylimidazolium (L) salt in the presence of oxalic acid (H2ox) are reported. The influence of the synthesis parameters, such as the nature of the lanthanide ion (Nd3+ or Sm3+), the nature of the imidazolium source (chloride [H2L][Cl] or zwitterionic [HL] form) and ...

Mahmoud Zarei was born in Hamedan, Iran in 1986. He received his B.Sc. in pure chemistry (2010) from Islamic Azad University Arak and M.Sc. in organic chemistry (2013) at Bu-Ali Sina University, Iran. Also, he received his Ph.D. in organic chemistry (2017) under the supervision of Prof. Mohammad Ali Zolfigol. He is currently working towards his postdoctoral under the supervision of Prof. Mohamm...

An efficient solventless one-pot procedure for the synthesis of imidazolium-based ionic liquid under microwave irradiation is described in which 1-methylimidazole was modified by organosilane (3-chloropropyl triethoxysilane). This ionic liquid 1-methyl-3-[(triethoxysilyl)propyl]imidazolium chloride (TMICl) is immobilized on Mechanically activated Fly Ash (MFA) by co-condensation method to d...

A spectroscopic investigation of complexes used to catalyze the oxidative carbonylation of toluene to p-toluic acid was conducted. Rhodium complexes were analyzed by (103)Rh and (13)C NMR, UV-visible spectroscopy, and infrared spectroscopy. In the presence of vanadium and oxygen, the resting state of the Rh-catalyst was found to exist as a Rh(III) complex with carbonyl and trifluoroacetate liga...