Non-fluorinated vinyldiazo compounds with trans-configuration irrespective of the nature of 3-R(1)-substituent (R(1) = H, Me, TBSO) even under ambient conditions easily cyclize to produce pyrazoles, while cis-stereoisomers undergo similar ring closure only at elevated temperatures or decompose to produce vinyloxocarbene reaction products. The 3-CF3-substituted analogues with cis- or trans-confi...

abstarct:a simple one-pot synthesis of pyrano[ 2,3-c]pyrazoles was developed by a three-component reaction of various benzaldehydes, malononitrile and 1-phenyl or hydro-3-methyl-1h-pyrazol-5(4h)-one in the presence of n-methyl pyridinium p-toluene sulfonate (nmpyts) as a catalyst. all of the synthesized compounds were identified by ir, 1h nmr, 13c nmr and mass spectroscopy techniques. in the me...

New multicomponent domino reactions of arylglyoxals with pyrazol-5-amines have been established, providing selective access to unprecedented pyrazolo-fused 1,7-naphthyridines, 1,3-diazocanes, and pyrroles (up to 52 examples). The unreported dipyrazolo-fused 1,7-naphthyridines were regioselectively synthesized through a special double [3 + 2 + 1] heteroannulation accompanied by direct C-C format...

BACKGROUND Isoxazoles exhibit interesting biological activities, and the 1,3-dipolar cycloaddition(13DC) reactions play an important role in both mechanistic and synthetic organic chemistry. Pyrazoles and annulated pyrazoles exhibit some diverse biological activities. They are used as antipyretic, analgesic drugs, tranquilizing, and herbicidal agents. Pyrazoles are also used extensively as usef...

The new 3,5-(substituted) pyrazoles and isoxazoles were prepared by reaction of (N'(1)E, N'(3)E)- N'(1), N'(3)-bis (3,4,5-substitutedbenzylidene)malonohydrazide with hydrazine hydrate and hydroxylamine hydrochloride respectively under solvothermal conditions involving an ecofriendly method without any environmental pollution, the yield are in the range of 75-96%. The structure of the new compou...

Pyrazoles are very important class of biologically active compounds and many of their derivatives are in clinical use. Pyrazole derivatives have been shown to exhibit antihyperglycemic [1], hypoglycemic [2] and fungicidal properties [3]. Some of them are also used as insecticides and herbicides [4,5]. Of the condensed pyrazoles, specially pyrano[2,3-c]pyrazole is a fused heterocycle comprising ...

A series of chalcone-based diarylpyrazoles containing a phenylsulphone or carbonitrile moiety was synthesized. Thus, 3-acetylpyrazoles 6a-c and 10a-c were used as useful substrates in facile synthesis of functional pyrazoles 7a-f and 11a-f, respectively. The anti-inflammatory activity and ulcerogenic effect were evaluated and some of the obtained products possessed a significant anti-inflammato...

Objective: Pyrazoles have wide application in medicinal chemistry because of diverse pharmacological activities. As a part of our ongoing research to identify potential inhibitors of cysteine proteases, these observations were guiding initiatives in the present work for the synthesis of some pyrazoles with a desire to see their inhibitory effect on endogenous proteolysis. Methods: We have synth...

Some N-acetyl pyrazoles including 3-(3,4-dichlorophenyl)-5-(substituted phenyl)-4,5-dihydro1 H-pyrazole-1-yl-ethanones have been synthesised by solvent free cyclization cum acetylation of chalcones including substituted styryl 3,4-dichlorophenyl ketones using hydrazine hydrate and acetic anhydride in presence of catalytic amount of fly-ash: H2SO4 catalyst. The yield of these N-acetyl pyrazole d...