نتایج جستجو برای: 28a

تعداد نتایج: 295  

Journal: :ACS medicinal chemistry letters 2013
Terry W Moore Kasinath Sana Dan Yan Stefanie A Krumm Pahk Thepchatri James P Snyder José Marengo Richard F Arrendale Andrew J Prussia Michael G Natchus Dennis C Liotta Richard K Plemper Aiming Sun

Targeting host cell factors required for virus replication provides an alternative to targeting pathogen components and represents a promising approach to develop broad-spectrum antiviral therapeutics. High-throughput screening (HTS) identified two classes of inhibitors (2 and 3) with broad-spectrum antiviral activity against ortho- and paramyxoviruses including influenza A virus (IAV), measles...

Journal: :Global Advances in Health and Medicine 2013

Journal: :Immunopharmacology and immunotoxicology 2010
Javad Arasteh Masoumeh Ebtekar Zahra Pourpak Ali Akbar Pourfatollah Zuhair Mohammad Hassan Tahereh Farahmandian

BACKGROUND AND AIM The utilization of umbilical cord blood transplantation (UCBT) has been increasing because of the potential advantage of rapid accessibility and the lesser risk of graft-versus-host disease (GVHD), thus allowing less strict HLA matching. IL-28A, also known as IFN-lambda2, has been regarded as a member of a new cytokine family that shares some features with type I interferon (...

Journal: :American journal of physiology. Renal physiology 1999
W Grady Campbell I David Weiner Charles S Wingo Brian D Cain

In the present study, we demonstrate that the rabbit cortical collecting duct cell line RCCT-28A possesses three distinct H-K-ATPase catalytic subunits (HKα). Intracellular measurements of RCCT-28A cells using the pH-sensitive dye 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) indicated that the mechanism accounting for recovery from an acid load exhibited both K+ dependence and sens...

2013
Saxe Gordon Lauray MacElhern

In this experiential Natural Healing and Cooking workshop, attendees will get a " taste " of how to use food as medicine. This session introduces attendees to a proven, practical, and delicious way to fight and protect against obesity, diabetes, heart disease, autoimmune disorders, and cancer—through the power of the plate. The founders of the UCSD Natural Healing and Cooking program encapsulat...

2011
Ourania Koltsida Michael Hausding Athanasios Stavropoulos Sonja Koch George Tzelepis Caroline Übel Sergei V Kotenko Paschalis Sideras Hans A Lehr Marcus Tepe Kevin M Klucher Sean E Doyle Markus F Neurath Susetta Finotto Evangelos Andreakos

IL-28 (IFN-λ) cytokines exhibit potent antiviral and antitumor function but their full spectrum of activities remains largely unknown. Recently, IL-28 cytokine family members were found to be profoundly down-regulated in allergic asthma. We now reveal a novel role of IL-28 cytokines in inducing type 1 immunity and protection from allergic airway disease. Treatment of wild-type mice with recombi...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2005
Stephan Brand Florian Beigel Torsten Olszak Kathrin Zitzmann Sören T Eichhorst Jan-Michel Otte Joachim Diebold Helmut Diepolder Barbara Adler Christoph J Auernhammer Burkhard Göke Julia Dambacher

Human cytomegalovirus virus (CMV) is a major cause of morbidity and mortality in immunocompromised individuals. Recently, a novel group of cytokines [interleukin (IL)-28A/B and IL-29, also termed interferon (IFN)-lambdas] has been described. Here, we demonstrate that intestinal epithelial cell (IEC) lines as well as murine and human colonic tissue express the IFN-lambda receptor subunits IL-28R...

2014
Yasuo Ouchi Jyunya Yamamoto Takashi Iwamoto

The Caenorhabditis elegans heterochronic gene pathway, which consists of a set of regulatory genes, plays an important regulatory role in the timing of stage-specific cell lineage development in nematodes. Research into the heterochronic gene pathway gave rise to landmark microRNA (miRNA) studies and showed that these genes are important in stem cell and cancer biology; however, their functions...

Journal: :American journal of physiology. Cell physiology 2007
Emily Cordas Anikó Náray-Fejes-Tóth Géza Fejes-Tóth

Serum- and glucocorticoid-induced kinase-1 (SGK1) is involved in aldosterone-induced Na(+) reabsorption by increasing epithelial Na(+) channel (ENaC) activity in cortical collecting duct (CCD) cells, but its exact mechanisms of action are unknown. Although several potential targets such as Nedd4-2 have been described in expression systems, endogenous substrates mediating SGK1's physiological ef...

Journal: :Molecules and cells 2008
Sun-Young Shin Il-Sup Kim Yul-Ho Kim Hyang-Mi Park Jang-Yong Lee Hong-Gyu Kang Ho-Sung Yoon

Maintaining redox balance is one of the crucial requirements for a cell to endure stress from the outside. Dehydroascorbate reductase (DHAR; EC 1.8.5.1) plays an important role in the ascorbate-glutathione cycle; one of the major ROS scavenging systems in most known biological systems. A cDNA clone of the DHAR gene from Oryza sativa (OsDHAR) was isolated and overexpressed in Escherichia coli BL...

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