To be able quickly find exact matches BLAST uses strategy of dot plots. Dot Plot is a table whose rows and columns are marked using sequences letters.For example: Identify internal repeats and inversions C A T D O G C A T G O D C * * A * * T * * D * * O * * G * * C * * A * * T * * G * * O * * D * * This dot plot allows us quickly identify internal repeats and inversions. Repeats are dot lines w...

The σ receptor was originally proposed to be a subtype of the opioid receptor. Abstract However, it is now clear that σ receptors are unique non-opioid, non-phencyclidine brain proteins. Two types of σ receptor exist, the σ-1 receptor and the σ-2 receptor. σ-1 receptors have been cloned and their distribution, physiological functions and roles in signal transduction were recently characterised....

Cholinesterases were detected in protoscolices of Echinococcus granulosus spectrophotometrically and electrophoretically. To characterize these activities as acetylcholinesterases or pseudocholinesterases, BW284C51 and the organophosphate anthelmintic Neguvón were assayed as specific inhibitors of acetylcholinesterases, while Iso-OMPA was employed as specific inhibitor of pseudocholinesterases....

The pharmacological activities of five metabolites of an anti-inflammatory compound, 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284) were investi gated and compared with TAI-284 and phenylbutazone. The metabolite IIb (cis 3'-hydroxy-cyclohexyl, β-form) was almost equivalent to TAI-284 regarding anti inflammatory activity as estimated by the carrageenin edema test, and was mor...

The X-ray crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with BW284C51 [CO[-CH(2)CH(2)-pC(6)H(4)-N(CH(3))(2)(CH(2)-CH=CH(2))](2)] is described and compared with the complexes of two other active-site gorge-spanning inhibitors, decamethonium and E2020. The inhibitor was soaked into TcAChE crystals in the trigonal space group P3(1)21, yielding a complex which dif...

Filariasis is a major health problem, affecting millions of people in tropical and subtropical regions of the world. Targeting the parasite specific enzyme is not only rational but essential for developing effective control measure against filariasis. In our earlier studies we have identified two isozymic forms of acetylcholinesterase (AchE) from bovine filarial parasites (Setaria cervi) differ...

Acetylcholinesterase (AChE) in the echinoid Lytechinus variegatus has been characterized. Kinetic parameters V(max), K(m), K(ss), and b were 2594+/-1048 nmol ATCh hydrolyzed/min/mg tissue wet weight, 185+/-11 microM, 308+/-100 mM, and 0.2, respectively for the substrate ATCh and 17.8+/-6.87 nmol BTCh hydrolyzed/min/mg tissue wet weight, 654+/-424 microM, 36+/-31 mM, and 0.6, respectively for BT...

AMA Lehmann M, Musialek P. MicroNET-covered stent use to seal carotid artery perforation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2023;19(3):284-288. doi:10.5114/aic.2023.131483. APA Lehmann, M., & Musialek, (2023). Interwencyjnej, 19(3), 284-288. https://doi.org/10.5114/aic.2023.131483 Chicago Márcio Francisco, and Piotr Musialek. 2023. "MicroNET-covered per...