Inherited mutations in BRCA1 confer susceptibility to breast and ovarian neoplasms. However, the function of BRCA1 and the role of BRCA1 in noninherited cancer remain unknown. Characterization of alternately spliced forms of BRCA1 may identify functional regions; thus, we constructed expression vectors of BRCA1 and a splice variant lacking exon 11, designated BRCA1 delta 672-4095. Immunofluores...

We propose a decoding method for the generalized algebraic geometry codes proposed by Xing et al. To show its practical usefulness, we give an example of generalized algebraic geometry codes of length 567 over F8 whose numbers of correctable errors by the proposed method are larger than the shortened codes of the primitive BCH codes of length 4095 in the most range of dimension.

Since its development, tariquidar (TQR; XR9576; N-[2-[[4-[2-(6,7Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]4,5-dimethoxyphenyl]quinoline-3-carboxamide) has been widely regarded as one of the more potent inhibitors of P-glycoprotein (P-gp), an efflux transporter of the ATP-binding cassette (ABC) transporter family. A third-generation inhibitor, TQR exhibits high affinity fo...

Completing everyday tasks often requires the execution of action sequences matched to a particular problem. To study the neural processes underlying these behaviors, we trained monkeys to produce a series of eye movements according to a sequence that changed unpredictably from one block of trials to the next. We then applied a decoding algorithm to estimate which sequence was being represented ...

Functional Materials Design, Discovery & Advanced Membranes & Porous Materials C Engineering, King Abdullah University of S 23955-6900, Kingdom of Saudi Arabia. E-m Department of Chemistry, University of S Tampa, Florida 33620, USA † Electronic supplementary information ( synthesis of ligands, NMR spectra, syn gures, PXRD, TGA, low and high pre analysis and IAST calculation. CCD crystallograph...

a Department of Chemistry & Biochemistry and Materials Science Institute, University of Oregon, Eugene, Oregon, USA 97403-1253. E-mail: [email protected]; Fax: +1-541-346-4643; Tel: +1-541-346-1695 b CAMCOR – Center for Advanced Materials Characterization in Oregon, University of Oregon, Eugene, OR 97403-1443, USA c Department of Chemistry, Earlham College, Richmond, IN 47374-4095 d Supramolecula...

The transcription factor p63 (Trp63) plays a key role in homeostasis and regeneration of the skin. The p63 gene is transcribed from dual promoters, generating TAp63 isoforms with growth suppressive functions and dominant-negative ΔNp63 isoforms with opposing properties. p63 also encodes multiple carboxy (C)-terminal variants. Although mutations of C-terminal variants have been linked to the pat...