A facile synthesis of novel polycyclic heterocycles namely naphthaquinoxaline and naphthazaquinoxaline derivatives is carried out by the reaction of lapachol and β-lapachone, naturally occurring naphthoquinones with o-phenylene diamine and 2,3-diaminopyridine. Regioselectivity in the reaction of β-lapachone with 2,3-diaminopyridine is confirmed by single crystal X-ray diffraction of a represent...

A convenient and general method for the synthesis in 26-73% yields of a new series of 7-alkyl(aryl/heteroaryl)-2-amino-5-trifluoromethyl-1,8-naphthyridines from direct cyclocondensation reactions of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones [CF₃C(O)CH=C(R¹)OR, where R¹ = H, Me, Ph, 4-MePh, 4-OMePh, 4-FPh, 4-BrPh, 4-NO₂Ph, 2-furyl, 2-thienyl and R = Me, Et] with 2,6-diaminopyridine (2,6-DAP), unde...

We studied the electrophysiological parameters of motor performance in eight patients with multiple sclerosis and troublesome fatigue, before and after treatment with 3,4-diaminopyridine. Symptomatic fatigue was evaluated by the Krupp Fatigue Severity Score and motor performance of adductor pollicis by transcranial magnetic stimulation, rapid voluntary movements and a fatiguing exercise test of...

2,6-Pyridinediylbisalkanamides were synthesized, using diaminopyridine (DAP) as a linker and alkyl chains of varying lengths, that upon self-assembly form submicron-sized sheets and their uptake into the cytoplasm of HeLa cells was studied by confocal microscopy.

Brine shrimp lethality of a new series of 16 to 26-membered macrocycles of iron(II) containing tetraaza groups and prepared by the template condensation reaction of diacarboxylic acids (malonic, succinic, glutaric or adipic) with 2,6-diaminopyridine and diethylenetriamine in 1:2:2 molar ratios have been studied. Structures and bonding of the macrocyclic complexes have been proposed based on ele...

2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. it is soluble in protic solvents. primary and secondary amines are n-methylated by various methods such as direct alkylation of amines with hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. consequently, they aren't...

We present a molecular docking study aimed to identify the binding site of protonated aminopyridines for the blocking of voltage dependent K(+) channels. Several active aminopyridines are considered: 2-aminopyridine, 3-aminopyridine, 4-aminopyridine, 3,4-diaminopyridine, and 4-aminoquinoleine. We apply the AutoDock force field with a lamarckian genetic algorithm, using atomic charges for the li...

The drug 3, 4 diaminopyridine (DAP) is a potassium channel blocker, closely related to 4-aminopyridine. Like 4-AP, DAP blocks the voltage-sensitive potassium channel. However, unlike 4-AP, DAP does not cross the blood brain barrier unless the barrier is broken. DAP therefore should be well suited for treating peripheral demyelination and have less central nervous system mediated side-effects. M...