نتایج جستجو برای: 249 were estimated
تعداد نتایج: 3620381 فیلتر نتایج به سال:
OBJECTIVES We compared the effectiveness of cefazolin versus cloxacillin in the treatment of MSSA bacteraemia in terms of mortality and relapse. METHODS A retrospective cohort study examined consecutive patients with Staphylococcus aureus bacteraemia from six academic and community hospitals between 2007 and 2010. Patients with MSSA bacteraemia who received cefazolin or cloxacillin as the pre...
The present study was undertaken to evaluate the osteogenic effect of Cervi cornu pantotrichum (CCP) on bone marrow stromal cells (BMSCs) which showed differentiation towards the osteoblastic phenotype. Cells were exposed to different culture medium (dexamethasone group, CCPE group and control group). The activities of osteoblastic markers such as alkaline phosphatase (ALP), bone gla protein (B...
High grain production of corn (Zea mays L.) can be maintained by adding inorganic N fertilizer, and also by using crop rotations that include alfalfa (Medicago sativa L.), but the relative impact of these management practices on soil quality is uncertain. We examined the effects on soil of N fertilization rate (0, 90, 180, 270 kg ha, corn phase only) in four cropping systems: CC, continuous cor...
Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...
Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can serve as the loci of drug-drug interactions (DDI). To support the evaluation of cynomolgusmonkey as a surrogate model for studying human organic cation transporters, monkey genes were cloned and shown to have a high degree of amino acid seq...
Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...
translation studies have become an accepted academic subject and books, journals and doctoral dissertations appear faster than one can read them all (bassnet and lefevere, 1990). but this field also brought with itself so many other issues which needed to be investigated more, in the heart of which, issues like ideology, ethics, culture, bilingualism and multilingualism. it is reported that ove...
PURPOSE Epilepsy is the third most common chronic brain disorder and is characterized by an enduring predisposition for seizures. Recently, a growing body of evidence has suggested that microRNA-146a (miR-146a) is upregulated in the brains of epilepsy patients and of mouse models; furthermore, miR-146a may be involved in the development and progression of seizures through the regulation of infl...
BACKGROUND There is limited evidence for the effectiveness of daclatasvir in patients whose hepatitis C threatens their life expectancy. The Named Patient Program in Europe included patients with advanced chronic hepatitis C, a life expectancy of less than 12 months and no other treatment options. METHODS A retrospective multi-country cohort of patients with chronic hepatitis C who received d...
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