Bortezomib is a highly selective inhibitor of the 26S proteasome and has been approved for clinical use in the treatment of relapsing and refractory multiple myeloma and mantle cell lymphoma. Clinical trials are also underway to assess the role of bortezomib in several other human malignancies, including leukemia. However, the mechanism(s) by which bortezomib acts remain to be fully understood....

There is evidence from epidemiological studies suggesting that increased consumption of cruciferous vegetables may protect against specific cancers more effectively than total fruit and vegetable intake. These beneficial effects are attributed to the glucosinolate breakdown products, isothiocyanates (ITC). Similarly, selenium (Se) consumption has also been inversely associated with cancer risk ...

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

Hand, foot and mouth disease (HFMD) is a common childhood infection caused by many enteroviruses, including enterovirus A71 (EV-A71). As EV-A71 is associated with severe neurological disease, early diagnosis is critical for clinical and public health management. In developing countries such as Malaysia, laboratory capacity to carry out EV-A71 IgM detection is greater than that of the gold stand...

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

Este artículo científico se centra en el papel esencial de la universidad como institución responsable educación y su importancia sociedad. La representa búsqueda verdad comprensión del universo todas las circunstancias vida. Como corporación estudiantes profesores, dedica a investigación, docencia contemplación verdad, promoviendo conocimiento integral formando profesionales para bien común. S...

A recurring theme in the tourism literature is how travelers and tourism businesses perceive the concept of diversity and uniqueness of attractions pinned to places called tourism destinations and respond to their perceptions. In this backdrop, the primary focus of this research is a reexamination of the unique selling proposition (USP) based tourism marketing practice that various Caribbean is...

Let M be a complex matrix of rank one, i.e. M = pq′ where p, q are complex nby-1 matrices and ′ denotes Hermitean conjugation. Let μC(M) and μR(M) denote the structured singular values μ(M,∆) of M defined with ∆ = ∆C and ∆ = ∆R respectively, where ∆C is the cone of all diagonal matrices with complex entries, and ∆R is the cone of all diagonal matrices with real entries. (a) Express μC(M) and μR...

Recognizing the importance and complexity of the concept of sustainability for tourism education, the purpose of this paper is to describe and refl ect upon the teaching and learning strategies for sustainability employed in an undergraduate tourism module. To aid in this discussion, this study frames the concept of sustainability as a threshold concept for tourism education. Th e notion of a t...