Defects in the human ferrochelatase gene lead to the hereditary disorder of erythropoietic protoporphyria. The clinical expression of this autosomal dominant disorder requires an allelic combination of a disabled mutant allele and a low-expressed nonmutant allele. Unlike most other erythropoietic protoporphyria populations, mutations identified among Swiss erythropoietic protoporphyria families...

Human functional imaging and neurocytology have produced important revisions to the organization of the cingulate gyrus and demonstrate four structure/function regions: anterior, midcingulate (MCC), posterior (PCC), and retrosplenial. This study evaluates the brain of a rhesus and 11 cynomolgus monkeys with Nissl staining and immunohistochemistry for neuron-specific nuclear binding protein, int...

Bioassays using pellets of agar, thatch-agar and turfgrass-agar were developed using benzimidazole-sensitive Penicillium expansum, to detect the fungicide methyl 2-benzimidazole carbamate (MBC) which is the major fungitoxic degradation product of benomyl [methyl 1-(butylcarbamoyl)-2-benzimidazole carbamate] in thatch and turfgrass clippings. These bioassays were used to estimate the amount of f...

Lynch syndrome is a genetic malignancy syndrome affecting the colon, endometrium, and other organs. It is difficult to find a Lynch syndrome patient without any family history of cancer. We have recently examined an endometrial cancer patient with a MSH2 gene mutation without a family history of cancer. A 55-year old Korean woman was admitted to a local clinic for vaginal bleeding. An endometri...

a bacterial septicaemia occurred in 3-female oscars (astronotus ocellatus) of about 2-year old held in 300l freshwater aquaria in south tehran. the external signs of infected fish consisted of lethargy, anaemia, distension (clinical dropsy), exophthalmia and cataract. internally there was a large amount of red-ascitic fluid accumulated in the abdominal cavity with haemorrhages/ hyperaemia of in...

Sweet pepper (Capsicum annuum L. CV. Keystone Resistant Giant #3) seeds were imbibed (primed) in salt solutions to determine a) what concentrations would inhibit radicle emergence and b) the influence this delay in radicle emergence would have on subsequent germination. Seeds were primed for 17 days at 23C in petri dishes with KNO3, KCl, NaCl, K2SO4, Na2SO4, 1 NaCl: 1 CaCl2 (mol/mol), Ca(NO3)2,...

The Saccharomyces cerevisiae methyltransferase encoded by TMT1 catalyzes the AdoMet-dependent monomethylation of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway. The biological significance of methylating 3-isopropylmalate and the relationship between Tmt1 and the leucine biosynthetic pathway is not yet established. We present evidence here showing that methylation of 3-i...

Xenorhabdus nematophila, a bacterium pathogenic for insects associated with the nematode Steinernema carpocapsae, releases high quantities of proteases, which may participate in the virulence against insects. Zymogram assays and cross-reactions of antibodies suggested that two distinct proteases were present. The major one, protease II, was purified and shown to have a molecular mass of 60 kDa ...