نتایج جستجو برای: 218

تعداد نتایج: 7562  

Journal: :Pediatric Critical Care Medicine 2018

2008
Hye Young Min

A review of computational methodsfor miRNA target prediction

2015
Miao Yang Ran Liu Xiajun Li Juan Liao Yuepu Pu Enchun Pan Yi Wang Lihong Yin Martin Pichler

miR-218, consisting of miR-218-1 at 4p15.31 and miR-218-2 at 5q35.1, was significantly decreased in esophageal squamous cell carcinoma (ESCC) in our previous study. The aim of this study was to determine whether aberrant methylation is associated with miR-218 repression. Bisulfite sequencing analysis (BSP), methylation specific PCR (MSP), and 5-aza-2'-deoxycytidine treatment assay were applied ...

Journal: :Molecular medicine reports 2014
Ruofan Dong Haifeng Qiu Guiqiang Du Yuan Wang Jinjin Yu Caiping Mao

We previously reported frequent loss of microRNA‑218 (miR‑218) in human cervical cancer, which was associated with tumor progression and poor prognosis. In this study, we investigated whether restoration of the miR‑218 level is a valid strategy for the treatment of cervical cancer. The expression of miR‑218 in cervical cancer samples and cell lines was quantified by reverse transcription TaqMan...

Journal: :International journal of clinical and experimental pathology 2014
Zhong-Di Xiao Chun-Yu Jiao Hai-Tao Huang Li-Jia He Jiu-Jun Zhao Zhao-Yang Lu Lian-Xin Liu

PURPOSE To investigate the regulatory mechanism of miR-218 in human hepatocellular carcinoma (HCC). METHODS qPCR was used to compare the expression levels miR-218 among six hepatocellular carcinoma cell lines and normal liver tissues. After transfecting MHCC97L cells with either miR-218 mimics or miR-218 inhibitor, western blotting was used to examine the expressing patterns of cyclinD1, p21,...

2017
Zhuoying Feng Luping Zhang Junchen Zhou Shuai Zhou Li li Xuyan Guo Guoying Feng Ze Ma Wenhua Huang Fei Huang

Glioma has become a significant global health problem with substantial morbidity and mortality, underscoring the importance of elucidating its underlying molecular mechanisms. Recent studies have identified mir-218 as an anti-oncogene; however, the specific functions of mir-218-1 and mir-218-2 remain unknown, especially the latter. The objective of this study was to further investigate the role...

2017
Zehang Zhuang Fengchun Hu Jing Hu Cheng Wang Jinsong Hou Zhiqiang Yu Tony T. Wang Xiqiang Liu Hongzhang Huang

Accumulating data suggest that microRNAs (miRNAs) play a pivotal role in the regulation of tumor cell sensitivity to chemotherapeutic agents. Although the roles of a few miRNAs have been identified in cisplatin resistance, little is known in regards to the concerted contribution of miRNA‑mediated biological networks. In the present study, we demonstrated that microRNA-218 (miR-218) was signific...

Journal: :Antimicrobial agents and chemotherapy 1990
I Szabó J Barabás A Tar L Kiss M Filep T Schmidt K Marossy B Tóth-Martinez G Barabás F Hernádi

The antibacterial activity of BK-218 was similar to that of cefamandole when it was tested against several laboratory strains. The inhibiting effect of BK-218 was greater than that of cephalexin and cefoxitin on penicillin-binding proteins of Escherichia coli HB101. This result was in close correlation with the relative inhibition of radiolabeled glucosamine incorporation (greatest with BK-218)...

2014
Wang Yuan Han Xiaoyun Qiu Haifeng Li Jing Hu Weixu Dong Ruofan Yu Jinjin Shen Zongji

We previously reported frequent loss of microRNA-218 (miR-218) in cervical cancer, which was associated with tumor progression and poor prognosis. As microRNAs were found invovled in the regulation of radiosensitivity in various human cancers, we therefore aim to investigate the effects of miR-218 on radiosensitivity of cervical cancer in the present study. The clonogenic survival assay demonst...

2017
Na Li Lufei Wang Guangyun Tan Zhiheng Guo Lei Liu Ming Yang Jin He

MicroRNA-218 (miR-218) has been implicated in the development and progression of multiple cancers. We investigated the role of miR-218 in ovarian cancer progression. We found that miR-218 expression levels were lower in ovarian cancer tissues and cell lines than in adjacent normal tissues or a normal ovarian cell line.miR-218 levels associated with International Federation of Gynecology and Obs...

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