Navitoclax (ABT-263), a Bcl-2 family inhibitor and ABT-199, a Bcl-2 selective inhibitor, are high molecular weight, high logP molecules that show low solubility in aqueous media. While these properties are associated with low oral bioavailability (F), both navitoclax and ABT-199 showed moderate F in preclinical species. The objective of the described study was to determine if lymphatic transpor...

The Internet backbone of many corporations carries two kinds of traffic: urgent and delayable. Shifting some traffic from peak periods to valleys reduces capacity requirements. We consider the case of managing the delayable traffic by an admission control (AC) system. AC gets link utilization feedback every τ seconds. Delayable opt-in sources obtain permission from AC to transmit for up to τ se...

Nature-based tourism's impact on environmental knowledge, attitudes, and behavior: a review and analysis of the literature and potential future research Nicole M. Ardoin, Mele Wheaton, Alison W. Bowers, Carter A. Hunt & William H. Durham a Graduate School of Education & Woods Institute for the Environment, Stanford University, 485 Lasuen Mall, Cubberley, Room 212, Stanford, CA, USA b Graduate S...

ion at the b-C. Relative yields are changed as much as a factor of 7.0 at 200 K, a factor of 5.0 at 298 K, and a factor of 3.7 in the other direction at 2400 K. The strong dependence of the product ratios on the multi-structural anharmonicity factors shows that such factors play an important role in controlling branching ratios in reaction mechanism networks.

Estrogen is a hormone critical in the development, normal physiology and pathophysiology1 of numerous human tissues2. The effects of estrogen have traditionally been solely ascribed to estrogen receptor a (ERa) and more recently ERb, members of the soluble, nuclear ligand–activated family of transcription factors3. We have recently shown that the seventransmembrane G protein–coupled receptor GP...

Concerns exist about adequacy of vitamin D in pregnant women relative to both maternal and fetal adverse health outcomes. Further contributing to these concerns is the prevalence of inadequate and deficient vitamin D status in pregnant women, which ranges from 5 to 84% globally. Although maternal vitamin D metabolism changes during pregnancy, the mechanisms underlying these changes and the role...

The application of cellulose acetate (CA) in various industrial areas is strongly influenced by thermal stability. Graphene nanoplatelets (GNPs) as a highly conductive filler promising choice to modify the stability CA, while practical effect falls short expectations associated with promise individually dispersed graphene owing poor dispersion. Supercritical carbon dioxide (SC-CO 2 ) favorable ...

OBJECTIVE To compare serum amyloid A (SAA) concentration, plasma fibrinogen concentration, total WBC count, and serum albumin-to-globulin concentration ratio (A:G ratio) in clinically normal (CN) and clinically abnormal (CA) horses. DESIGN Prospective cohort study. ANIMALS 111 CN horses and 101 CA horses hospitalized at a specialty clinical practice. PROCEDURES Shortly after admission, a ...