The introduction of TNF inhibitors more than a decade ago marked the beginning of an exciting era in the management of RA. Despite the development of biologics with alternative modes of action, TNF inhibitors remain today the most widely prescribed class of biologics for RA. However, tuberculosis (TB) is a major safety concern with TNF inhibitors. The risk of active TB is increased up to 56-fol...

Nearly every major process in a cell is carried out by assemblies of multiple dynamically interacting protein molecules. To study multi-protein interactions within such molecular machineries, we have developed a fluorescence microscopy method called three-chromophore fluorescence resonance energy transfer (3-FRET). This method allows analysis of three mutually dependent energy transfer processe...

The present study measured eight PBDE congeners' (BDE-28, 47, 99, 100, 153, 154, 183, and 209) exposure via ingestion of indoor dust and soil, inhalation, and food consumption. Contributions to PBDEs exposure from different media revealed that indoor dust (dust suspended in air) was not an important exposure route for PBDE congeners for adults in Shenzhen, China. Food consumption contributed mo...

The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places increased relative to the sleep session before exploration. This cofiring increas...

Abnormal, 143 Abnormality degree, 144 ABox, 19 simple, 175 Absorption, 102 Abstract feature, 134, 229 AL, 232 ALC, 10, 107, 117, 232 ALCEU , 232 ALCI, 39, 90 ALCO, 41 ALCOI, 123 ALCQ, 40 ALCOIQ, 125 ALEU , 233 And-branching, 101 Annotation, 221 property, 221 Anonymous individual, 219 ans(q, I), 170 Answer, 173 to conjunctive query, 170 to Datalog program, 194 Assertion concept, 19 negated role,...

Dynamic Efficiency and Pareto Optimality in a Stochastic OLG Model with Production and Social Security We analyze the interaction between risk sharing and capital accumulation in a stochastic OLG model with production. We give a complete characterization of interim Pareto optimality. Our characterization also subsumes equilibria with a PAYG social security system. In a competitive equilibrium i...

In a recent clinical trial, HLA-A2+ melanoma patients were vaccinated with a peptide derived from the melanoma Ag gp100, which had been modified at the second position (g9-209 2M) to enhance MHC binding affinity. Vaccination led to a significant increase in lymphocyte precursors in 10 of 11 patients but did not result in objective cancer responses. We observed that some postvaccination PBMC cul...