Technologic advances now make it possible to collect large amounts of genetic, epigenetic, metabolomic and gut microbiome data. These data have the potential to transform approaches towards nutrition counselling by allowing us to recognise and embrace the metabolic, physiologic and genetic differences among individuals. The ultimate goal is to be able to integrate these multi-dimensional data s...

In many invertebrates, the nuclearization of β-catenin at one pole of the embryo initiates endomesoderm specification. An intriguing possibility is that a gradient of nuclear β-catenin (nβ-catenin), similar to that operating in vertebrate neural tube patterning, functions to distinguish cell fates in invertebrates. To test this hypothesis, we determined the function of nβ-catenin during the ear...

Background: Clinical supervision has gained wide recognition in recent years as an essential component of a practitioner’s continuing professional development. However, confusion exists in professional literature regarding the most effective models, styles, processes and methods of clinical supervision. Aim: This article outlines the elements required to establish and sustain an effective clini...

Secondary education needs to find learning strategies that favor student engagement, particularly in socially deprived communities. The objective of this study is analyze the influence gamification on educational flow and academic performance. A quasi-experimental pre-test/post-test has been carried out with 207 secondary school students compares gamified cooperative method directive teaching m...

Traditional systems of medicine, also known as complementary and alternative medicine (CAM), have been in practice in Southeast Asia since time immemorial. These systems, which originated in India (Ayurveda), China [herbal medicine, acupuncture, massage (tui na), exercise (qigong)] and Greece Persia (Unani system) are still prevalent worldwide, along with other forms, including Tibetan medicine...

Estrogen is a hormone critical in the development, normal physiology and pathophysiology1 of numerous human tissues2. The effects of estrogen have traditionally been solely ascribed to estrogen receptor a (ERa) and more recently ERb, members of the soluble, nuclear ligand–activated family of transcription factors3. We have recently shown that the seventransmembrane G protein–coupled receptor GP...

Youth purpose is defined as a life aim that both personally meaningful and contributes to the world beyond self. This study disaggregated other-oriented (OO) aims (i.e., intended contribute world) self-oriented (SO) without intention self) examine development of youth who evince various combinations high low OO SO aims. In sample 207 adolescent girls, hierarchical cluster analysis revealed thre...

Navitoclax (ABT-263), a Bcl-2 family inhibitor and ABT-199, a Bcl-2 selective inhibitor, are high molecular weight, high logP molecules that show low solubility in aqueous media. While these properties are associated with low oral bioavailability (F), both navitoclax and ABT-199 showed moderate F in preclinical species. The objective of the described study was to determine if lymphatic transpor...