Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Wickham Chen, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1402. Fax: 214-768-3573. Email: [email protected] Tiankuan Liu, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1541. Fax: 214-768-4095. Email: [email protected] Ping Gui, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1733. Fax: 214-768-3573. Email: [email protected] Annie C...

Wickham Chen, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1402. Fax: 214-768-3573. Email: [email protected] Cheng-An Yang, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1641. Fax: 214-768-4095. Email: [email protected] Junheng Zhang, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1402. Fax: 214-768-3573. Email: [email protected]...

Continuing growth in link speeds and the number of advertised IP prefixes places increasing demands on the performance of Internet routers. An Internet Service Provider (ISP) requires routers to be able to accommodate up to 500,000 prefixes and very likely 1M in the near future. Also the prefix length is expected to grow from (up to) 32 bits to 128 bits with the introduction of IPv6. While tern...

Radiotherapy, a therapeutic modality of cancer treatment, nonselectively damages normal tissues as well as tumor tissues. The search is ongoing for therapeutic agents that selectively reduce radiation-induced normal tissue injury without reducing tumoricidal effect, thereby increasing the therapeutic ratioof radiation therapy. Our laboratory established 5-(4-methylpiperazin-1-yl)2-[2ʹ-(3,4-dime...

Blow flies of the genus Hypopygiopsis are considered forensically important. In Thailand, four Hypopygiopsis species coexist, i.e., Hypopygiopsis fumipennis, Hypopygiopsis infumata, Hypopygiopsis violacea and Hypopygiopsis tumrasvini. In this study, the ontogeny and developmental rate of H. tumrasvini eggs, larvae and pupae were determined in the laboratory chamber reared at 25.0±2.0°C and 80.0...

In this issue of Rheumatology, Gaujoux-Viala et al. [1] studied a cohort (ESPOIR) with early rheumatoid arthritis (ERA) where 813 patients were followed up for more than 2 years and rated their quality of life (QoL). This valuable study demonstrates that initially 11% and later 3.3% have a utility that is worse than death, which translates as death being a better quality of life than their curr...

CFTR (cystic fibrosis transmembrane conductance regulator), the protein whose dysfunction causes cystic fibrosis, is a chloride ion channel whose gating is controlled by interactions of MgATP with CFTR's two cytoplasmic nucleotide binding domains, but only after several serines in CFTR's regulatory (R) domain have been phosphorylated by cAMP-dependent protein kinase (PKA). Whereas eight R-domai...

The use of an ESI SC FAST autosampler coupled to a Perkin Elmer Optima 7300 DV ICP can dramatically improve productivity for the analysis of environmental samples using EPA SW-846 Method 6010C. Sample throughput, as determined by sample-to-sample run time can be improved by as much as 100% as compared to traditional sample introduction systems and autosampler configurations. Both sample analysi...