Marked hyperleptinaemia and metabolic acidosis are common findings in patients with chronic renal failure. In animal models, both leptin administration and acidosis reduce food intake. However, leptin causes loss of body fat, while acidosis induces muscle wasting. Whether a low pH and leptin production are related has not been studied. Leptin secretion was measured in cultured 3T3-L1 adipocytes...

3. Nadeau JH, Taylor BA “Lengths of chromosomal segments conserved since divergence of man and mouse” Proc. Natl. Acad. Sci, 81(814-818), 1984 4. Wienberg J ‘The evolution of eutherian chromosomes” Curr. Opin. Genet. Dev. 14(657666), 2004 5. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Argawala R, Ainscough R, Alexandersson M, An P “Initial sequencing and comparative a...

Natural killer (NK) cell activity is severely impaired in untreated patients with hairy cell leukemia (HCL). In an attempt to investigate whether this impairment is related to a defect at the target cell binding and/or at the post target cell binding level, we evaluated the peripheral blood mononuclear cells (PBMC) of HCL patients for their ability to: (1) bind and kill K-562 NK-sensitive targe...

An up-to-date publication on the history and methodology of legal science review A. Malinovsky’s textbook “History Legal science: Textbook” (Moscow: Prometheus Publ., 2022. 562 p.)

This article provides a brief analysis of the Court Justice EU decision 16 March 2021, C 562/19 P European Commission v Republic Poland, addressing issues state aid and progressive turnover taxation.

* R. Alrashedi, corresponding author, Faculty of Graduate and Postdoctoral Studies, University of Ottawa. E-mail: [email protected]. Phone: (613) 562-5129. Fax: (613) 562-5129. A. Persaud, Telfer School of Management, University of Ottawa. Email: [email protected]. Phone: (613) 562-5800, ext. 6189. Fax: (613) 562-5164. Gurprit Kindra, Telfer School of Management, University of Ot...

UNLABELLED Adults with sickle cell disease(SCD) are a growing population. Recent national estimates of outcomes in acute chest syndrome(ACS) among adults with SCD are lacking. We describe the incidence, outcomes and predictors of mortality in ACS in adults. We hypothesize that any need for mechanical ventilation is an independent predictor of mortality. METHODS We performed a retrospective an...

thrombin is a multifunctional enzyme which has key roles in coagulation cascade and inflammatory events. the pro-inflammatory functions of thrombin occur by different mechanisms including increasing mast cell degranulation, up-regulating the expression of cell adhesion molecules (cams) and promoting the secretion of inflammatory chemokines and cytokines. dysregulated signaling functions of thro...