background: breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. the purpose of this study was to determine the relationship between estrogen and progesterone receptors with her-2, ki67, p53, and clinicopathologica...

background: recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society. recently a few numbers of genetic polymorphisms in kinase insert domain-containing receptor (kdr) gene are examined that can endanger the life of the fetus in pregnant women. objective: the risk of kdr gene polymorphisms was inves...

the present study describes the changes in expression of hydroxy- carboxylic acid receptor 2 (hca2 receptor) in femoral epiphysis and metaphysis of rats with glucocorticoid-induced osteoporosis (gio). 16 growing male sprauge dawley rats were randomly divided into two equal groups consisting of normal control and rats that were rendered osteoporotic by receiving 0.1 mg/kg/day dexamethasone throu...

crouzon syndrome is a rare autosomal dominant premature cranyosynostosis, caused by fibroblast growth factor receptor 2 gene mutation on chromosome 10. the predominant skull and facial malformations with potential compromise airway make the crouzon syndrome a demanding issue for anesthesiologists and surgeons, required dynamic team work. in this report we describe a child, a known case of crouz...

b a ckground:  the purpose of our study was to investigate the possible effect of  bsm i vitamin d receptor (vdr’s) polymorphism on changes of the inflammatory and oxidative stress (os) biomarkers in response to daily intake of vitamin d- fortified yogurt drink ( doogh ) in subjects with type 2 diabetes (t2d). m ethods : in a randomized controlled trial, 100 t2d subjects were allocated to two g...

Synthetic cannabinoids (SC) are a heterogeneous group of substances with a high affinity for cannabinoid receptors. Unlike Δ9-tetrahydrocannabinol (THC), synthetic cannabinoids are incredibly potent, highly productive, have more affinity for the Cannabinoid receptor type 1 (CB1), and Cannabinoid receptor type 2 (CB2), and are designed to accelerate the effects of tetrahydrocannabinol. Also, the...

Objective(s): Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in elderly type 2 diabetes using a rat model and to provide experimental evidence for insulin resistance improvement by magn...

Coronaviruses (CoVs) are a group of viruses that induce infection in the respiratory and other systems in the human body. There are two coronaviruses that transmitted from animals to humans including severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) (1). The novel coronavirus that appeared at first in Wuhan, China, in December 2019 was named as severe acut...

new derivatives of 2-[2-(2-chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. in pharmacological evaluatio...