6,7-Diethoxy-1-[1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridin- 4-yl]naphthalene-2,3-dimethanol [T-440, (1)] is a potential anti-asthmatic agent based on selective phosphodiesterase 4 inhibition. It was necessary for the further evaluation of 1 to develop an efficient synthetic route for 1, especially the construction of the 1-(2-methoxyethyl)-2-pyridone moiety. We examined an N-selective alkylati...

The crystal structure of the title compound, C(6)H(7)NO, is stabilized by inter-molecular N-H⋯O hydrogen bonds, resulting in inversion dimers. The structure is further consolidated by weak C-H⋯O hydrogen bonds.

2-Pyridone (PD), converting to 2-hydroxypyridine (HP) through a lactam-lactim isomerization mechanism, can form three different cyclic dimers by hydrogen bond formation: (PD)(2), (PD-HP), and (HP)(2). We investigate the complexation chemistry of pyridone in dichloromethane-d(2) using a combined NMR and Fourier transform infrared (FT-IR) approach. Temperature-dependent (1)H NMR spectra indicate ...

The asymmetric unit in the title compound, C(5)H(5)NO, comprises two independent but virtually identical mol-ecules of 2-pyridone, and represents a monoclinic polymorph of the previously reported ortho-rhom-bic (P2(1)2(1)2(1)) form [Penfold (1953 ▶). Acta Cryst.6, 591-600; Ohms et al. (1984 ▶). Z. Kristallogr.169, 185-200; Yang & Craven (1998 ▶). Acta Cryst. B54, 912-920]. The independent mol-e...

Leontidine and camoensine, the main representatives of small quinolizidine-indolizidine alkaloid subgroup, are characterized by an inner bispidine system to which a 2-pyridone pyrrolidine fused on opposite sides. We efficiently synthesized both natural products from commercially available abundant cytisine, was converted into key intermediate, N-Boc-11-oxocytisine, iodine oxidation protection. ...

Novel substituted bis-(3-cyano-2-pyridone) derivatives were prepared via a powerful method using enaminonitriles push–pull dienes as key building blocks. The synthesis was performed in three steps from easily accessible starting materials good yields. All target products structurally elucidated by spectroscopic data. reaction mechanism for formation of bis (3-cyano-2-pyridone) proposed. structu...

An improved synthesis of 3-hydroxy-4-pyridone via an Elbs oxidation of 4-pyridone and isolation of 4-pyridone-3-sulfate is described.

The development of a rapid method for the determination of N-methyl2-pyridone-5-carboxamide (pyridone) in urine (1) has made it practical to attempt to confirm and extend the studies of Holman and de Lange (2) and others (3-5) concerning the excretion of the pyridone following the administration of various known or possible precursors to man. In the conversion of nicotinic acid to the pyridone ...