Carrion smell is strongly repugnant to humans and triggers distinct innate behaviors in many other species. This smell is mainly carried by two small aliphatic diamines, putrescine and cadaverine, which are generated by bacterial decarboxylation of the basic amino acids ornithine and lysine. Depending on the species, these diamines may also serve as feeding attractants, oviposition attractants,...

Inward rectification induced by mono- and diaminoalkane application to inside-out membrane patches was studied in Kir2.1 (IRK1) channels expressed in Xenopus oocytes. Both monoamines and diamines block Kir2.1 channels, with potency increasing as the alkyl chain length increases (from 2 to 12 methylene groups), indicating a strong hydrophobic interaction with the blocking site. For diamines, but...

The synthesis of 1,4-diamines containing the (Z)-1,4-diaminobut-2-ene subunit via a temporary phosphorus tether/RCM strategy is described. We have developed a new method utilizing phosphorus nuclei as suitable temporary tethers for the coupling of nonracemic allylic amines. This approach allows for the generation of C(2)-symmetric and unsymmetric 1,4-diamines 1-3, which may have considerable sy...

an efficient synthesis of trialkyl (e)-3-(3-oxo-2-3,4-dihydro-2-(1h)-quinoxalinylidene)-prop-1-ene-1,2,3-tricarboxylate derivatives via a simple three-component reaction between benzene-1,2-diamines with dialkyl acetylenedicarboxylates in the presence of k2co3-peg catalytic system at 100 oc was reported. the desired products were obtained in excellent yields (88-92%). various benzene-1,2-diamin...

Radical translocation facilitates the regioselective ?-amination of 2-alkyl-substituted azacycles, leading to 1,3-diamines including alkaloidal natural product tetraponerine T8.

Treatment of Ehrlich-ascites-carcinoma-bearing mice with methylglyoxal bis(guanylhydrazone) alone or in combination with 2-difluoromethylornithine greatly enhanced the transfer of intragastrically administered radioactive putrescine and cadaverine into the carcinoma cells. Difluoromethylornithine alone did not have any effect on the accumulation of intestine-derived diamines in the tumour cells...

A novel method to prepare 2-H-imidazolines from glyoxylic acid monohydrate and 1,2-diamines is described; the key reaction of this method is the oxidative decarboxylation of the 2-carboxy imidazolidines by NBS.

The reaction of 1,4-Dihydroxyanthraquinone with diamines was carried out in the presence of CuCl(2), CuCl in the ionic liquid [Bmim]PF(6), [Bmim]BF(4) or [Bmim]Cl x CuCl.

von Braun Cyanogen Bromide Reaction Some extensions of von Braun cyanogen bromide reaction have been undertaken on conessine, isoconessine and two simpler bases, dimethyl a-naphthyl amine and diethyl amine. The monocyanamides of conessine and isoconessine yielded acid amides, aminoderivatives (diamines) and guanido derivatives on careful hydrolysis, reduction and treatment with ammonia, respect...

1-Iodonaphthalene-2,4-diamines in trifluoroacetic acid/chloroform give stable Wheland-like tetrahedral cationic species observable by NMR, through an initial intramolecular protonation. Dynamic equilibria allow proton-deuterium exchange of aromatic protons and provide a mechanism for deiodination of 1-iodonaphthalene-2,4-diamines.