2-Aminothiazolobenzazepine (2-ATBA), 7-[(1-methyl-1H-pyrazol-4yl)methyl]-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepin2-amine, is a D2 partial agonist that has demonstrated antipsychotic effects in a rodent in vivo efficacy model. The metabolite profile showed that 2-ATBA is mainly metabolized by oxidation. However, identification of the oxidation site(s) in the 2-aminothiazole group ...

We propose a novel pathway for the prebiotic synthesis of 2'-deoxynucleotides. Consideration of the constitutional chemical relationships between glycolaldehyde and β-mercapto-acetaldehyde, and the corresponding proteinogenic amino acids, serine and cysteine, led us to explore the consequences of the corresponding sulfur substitution for our previously proposed pathways leading to the canonical...

A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.

The chemical oxidative polymerization of 2-aminothiazole (AT) was studied in aqueous solution using copper chloride (CuCl2) as an oxidant. The effect of varying the reaction temperature, reaction time and oxidant/monomer molar ratio on the polymer yield was investigated. The resulting poly(2-aminothiazole)s (PATs) were characterized by FTIR, 1H NMR, UV-vis, gel permeation chromatography, scanni...

The article shows the antioxidant properties of new derivatives 2-aminothiazole containing diterpene fragment. Using method luminol-dependent chemiluminescent analysis it is revealed that tested compounds under investigation exhibit in model test systems, where processes reactive oxygen species formation, lipid peroxidation, and cell phagocytosis blood are induced.

Potential synthesis of a series of 3-amino-4arylazothiophene derivatives from reaction of 2-cyano-2phenylthiocarbamoyl acetamide and the appropriate α-halogenated reagents, followed by coupling with different aryl diazonium salts (Japp-Klingemann reaction), and another series of 5-arylazo-thiazol2-ylcarbamoyl-thiophene derivatives from base-catalyzed intramolecular condensation of 5-arylazo-2-(...