two deoxyglucose (dg) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-d-glucose (ecb-dg) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-d-glucose (dhp-dg), were synthesized and radiolabeled successfully with [99mtc(h2o)3(co)3]+ complex. [99mtc]-ecb-dg and [99mtc]-dhp-dg complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mci of na99mtco4 in 1 ml saline. radi...

Circulating tumor cells (CTCs) play an essential role in metastasis and serve as important prognostic biomarker. The technology of CTC labeling detection vivo can greatly improve the research cancer therapy. However, there is no to detect CTCs clinic. In this study, we demonstrate that 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose (2-NBDG), a 2-deoxy-glucose analog, work ind...

Gluconacetobacter xylinus (5Acetobacter xylinum) ATCC 10245 incorporated 2-amino-2-deoxy-D-glucose (glucosamine) and 2-acetamido-2-deoxy-D-glucose (N-acetylglucosamine), but not 3-O-methyl-D-glucose or 2-deoxyD-glucose into exopolymers. Incorporation was confirmed by gas chromatography with and without mass spectrometry, Fourier transform infrared, and H nuclear magnetic resonance. The average ...

LIKUSKI, HENRY J., ALBERT F. DEBONS, AND ROGER J. CLOUTIER. Inhibition of go Id thioghcose-induced hypothalamic obesity by glucose analogues. Am. J. Physiol. 2 12(3) 669-676. 1967.--Female CBA mice were used to determine the effect of the glucose inhibitors, 2-deoxy-n-glucose and 2-amino-2-deoxy-oglucose on gold thioglucose-induced hypothalamic obesity. A marked inhibition in the incidence of o...

LIKUSKI, HENRY J., ALBERT F. DEBONS, AND ROGER J. CLOUTIER. Inhibition of go Id thioghcose-induced hypothalamic obesity by glucose analogues. Am. J. Physiol. 2 12(3) 669-676. 1967.--Female CBA mice were used to determine the effect of the glucose inhibitors, 2-deoxy-n-glucose and 2-amino-2-deoxy-oglucose on gold thioglucose-induced hypothalamic obesity. A marked inhibition in the incidence of o...

In order to get insights into the feedback regulation by tyrosine of the Escherichia coli chorismate mutase/prephenate dehydrogenase (CM/PDH), which is encoded by the tyrA gene, feedback-inhibition-resistant (fbr) mutants were generated by error-prone PCR. The tyrA(fbr) mutants were selected by virtue of their resistance toward m-fluoro-D,L-tyrosine, and seven representatives were characterized...

1. The deoxyfluoro-d-glucopyranose 6-phosphates are substrates for both yeast and rat liver glucose 6-phosphate dehydrogenase. 2. The V(max.) values (relative to d-glucose 6-phosphate) were determined for a series of d-glucose 6-phosphate derivatives substituted at C-2. The V(max.) values decreased with increasing electronegativity of the C-2 substituent. This is consistent with a mechanism inv...