Ca(2+) sensitization of smooth muscle contraction involves inhibition of myosin light chain phosphatase (SMPP-1M) and enhanced myosin light chain phosphorylation. Inhibition of SMPP-1M is modulated through phosphorylation of the myosin targeting subunit (MYPT1) by either Rho-associated kinase (ROK) or an unknown SMPP-1M-associated kinase. Activated ROK is predominantly membrane-associated and i...

A comparison of urinary alpha 1-microglobulin concentrations to the behaviour of other indicators of renal tubular disorders, beta 2-microglobulin, retinol-binding protein and N-acetyl-beta-D-glucosaminidase (NAG) has been made. In acute tubular disorders the concentrations of urinary beta 2M and RBP are highly correlated (r = 0.89) but this is less marked for alpha 1M and beta 2M (r = 0.55) an...

HAP46/BAG-1M and its isoforms affect the protein-folding activities of mammalian HSP70 chaperones. They interact with the ATP-binding domain of HSP70 or HSC70, leaving the substrate-binding site available for further interactions. Trimeric complexes can therefore form with, for example, transcription factors. Moreover, HAP46/BAG-1M and the larger isoform HAP50/BAG-1L bind to DNA non-specificall...

Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. An appropriate exchange rate of ADP/ATP is crucial for chaperone-dependent protein ...

Let M be a lattice module over the multiplicative lattice L. A nonzero L-lattice module M is called second if for each a ∈ L, a1M = 1M or a1M = 0M . A nonzero L-lattice module M is called secondary if for each a ∈ L, a1M = 1M or a(n)1M = 0 M for some n > 0. Our objective is to investigative properties of second and secondary lattice modules.

This paper investigates the microstructures and the polarization behaviors of Al7.5Cr22.5Fe35Mn20Ni15 high-entropy alloy in 1M (1 mol/L) deaerated sulfuric acid (H2SO4), nitric acid (HNO3), and hydrochloric acid (HCl) solutions at temperatures of 30–60 ̋C. The three phases of the Al7.5Cr22.5Fe35Mn20Ni15 high-entropy alloy are body-centered cubic (BCC) dendrites, face-centered cubic (FCC) interd...

U. Introduction In Doyle and Bricksen [1956. p. 77] it is observed that the Cauchy stress tensor 0 can be derived by varying the internal energy e with respect to the Riemannian metric on space: oab =Zpae/agab. Their formula has gone virtually unnoticed in the elasticity literature. In this lecture we shall explain some of the reasons why this formula is, in fact, of fundamental significance. S...

Members of the metallothionein (MT) family are involved in metal detoxifcation and in the protection of cells against certain electrophilic carcinogens. In present study, it was found that MT1M was downregulated in more than 77.1% (91/118) of hepatocellular carcinoma (HCC) tissues compared with adjacent non-tumor tissues. Furthermore, overexpression of MT1M inhibited cell viability, colony form...