The aim of this study was to examine the birthdates distribution of French male soccer players (n = 363,590) who dropped out during or after the 2006-2007 season, to determine whether the relative age effect is linked to dropout behaviour. An over-representation of players born late in the competitive year was observed among dropouts, from the U-9 to the U-18 age categories, whereas their count...

BRITTA SIEGMUND,1 GIAMILA FANTUZZI,1 FLORIAN RIEDER,2 FABIA GAMBONI-ROBERTSON,3 HANS-ANTON LEHR,4 GUNTHER HARTMANN,2 CHARLES A. DINARELLO,1 STEFAN ENDRES,2 AND ANDREAS EIGLER2 Departments of 1Medicine and 3Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80206; 2Division of Clinical Pharmacology, Medizinische Klinik Innenstadt, Klinikum of the Ludwig-Maximilians-Universi...

1. Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values, and (c) brisk initial increases in plasma 18-hydroxydeoxy...

2,4-dithiouracil (DTU) forms in the crystals the H-bonded monohydrates of a 1:1:1 ratio with 18-crown-6 (18C6) 1, cis,syn,cis-isomer of dicyclohexano-18-crown-6 (DCH6A) 2, and benzo-18-crown-6 (B18C6) 3, while the anhydrous adduct with cis,anti,cis-isomer of dicyclohexano-18-crown-6 (DCH6B) 4 is of a 2:1 ratio. In 1-3 the components reproducibly alternate in the chains, while in 4 the chains ar...

Application of a fluoroiodine analogue of the Togni reagent was studied in fluorocyclization reactions. In the presence of a transition-metal catalyst the applied fluoroiodine reagent can be used for aminofluorination, oxyfluorination, and carbofluorination reactions. The described procedure has a very broad synthetic scope for preparation of functionalized hetero- and isocyclic compounds havin...