Cilia are microtubule-based organelles that are present on most cells and are required for normal tissue development and function. Defective cilia cause complex syndromes with multiple organ manifestations termed ciliopathies. A crucial step during ciliogenesis in multiciliated cells (MCCs) is the association of future basal bodies with the apical plasma membrane, followed by their correct spac...

Free radicals are implicated in several diseases of prematurity. The study aimed to correlate plasma antioxidants levels and lipid peroxidation between maternal and cord blood in normal and preterm deliveries. Superoxide dismutase (SOD), Reduced Glutathione (GSH) and Uric acid were the measured antioxidants while Malondialdehyde (MDA) was an index of lipid peroxidation. 32 mothers who delivered...

Studies on signalling dynamics in living embryos have been limited by a scarcity of in vivo reporters. Tandem fluorescent protein timers provide a generic method for detecting changes in protein population age and thus provide readouts for signalling events that lead to changes in protein stability or location. When imaged with quantitative dual-colour fluorescence microscopy, tandem timers off...

The network theory of the immune system proposes that idiotype-anti-idiotype interactions provide important immunoregulatory controls (1). In many experimental systems, the passive administration of heterologous anti-idiotypic ant ibody has been shown to enhance (2) or suppress (3) immune responses. In addition, spontaneous auto-anti-idiotypic antibody has been detected after antigenic challeng...

We explore the ability of optimal foraging theory to explain the observation among marine bacteriophages that host range appears to be negatively correlated with host abundance in the local marine environment. We modified Charnov's classic diet composition model to describe the ecological dynamics of the related generalist and specialist bacteriophages phiX174 and G4, and confirmed that special...