objective(s)the purpose of this study holds, for the first time, an evaluation of the intraperitoneal curcumin lavage on the development of post-operative intra-abdominal adhesions.materials and methodsthirty male wistar rats were randomized into five groups. the rats were administered anesthesia and underwent surgery in order to create intra-abdominal adhesions. before the abdomen was closed, ...

introduction: cholestasis is impairment of normal bile excretion into the duodenum and classified as mechanical and non mechanical cholestasis. mechanical cholestasis presents with increase in bile duct diameter or obstruction in bile duct in an ercp. cholestasis leads to different complications. one of these complications is mucosal peptic erosion leading to gastrointestinal bleeding, perforat...

Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent. The systemic bioavailability of curcumin is low, perhaps attributable, at least in part, to metabolism. Indirect evidence suggests that curcumin is metabolized in the intestinal tract. To investigate this notion fu...

BACKGROUND AND AIM Chronic cholangiopathies have limited therapeutic options and represent an important indication for liver transplantation. Curcumin, the yellow pigment of the spice turmeric, has pleiotropic actions and attenuates hepatic damage in animal models of chemically-induced liver injury. Whether curcumin has beneficial effects in cholangiopathies is unknown. METHODS Potential anti...

BACKGROUND 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) activates glucocorticoid locally in liver and fat tissues to aggravate metabolic syndrome. 11β-HSD1 selective inhibitor can be used to treat metabolic syndrome. Curcumin and its derivatives as selective inhibitors of 11β-HSD1 have not been reported. METHODOLOGY Curcumin and its 12 derivatives were tested for their potencies of inhibitor...

Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA), have been thought to be mediated by the cytokine interleukin 17 (IL-17). Curcumin (1,7-Bis (4-hydroxy-3methoxyphenyl)-1,6 heptadiene3, 5-di-one) is an active ingredient derived from rhizomes of Curcuma longa Linn., displaying remarkable anti-inflammatory. Curcumin has been reported to have the suppressive effect on the develop...

Objective(s):  The cholinergic system plays an important role in learning and memory. This study investigated the effects of curcumin (turmeric extract) and the cholinergic system and their interaction on memory retention of passive avoidance learning in adult male Wistar rats. Materials and Methods: At first, an injection cannula was implanted in right ventricles of the animals. One week afte...

Inhibition of the bile salt export pump (BSEP) has been recognized as a key factor in the development of drug-induced cholestasis (DIC). The risk of DIC in humans has been previously assessed using in vitro BSEP inhibition data (IC50) and unbound systemic drug exposure under assumption of the "free drug hypothesis." This concept, however, is unlikely valid, as unbound intrahepatic drug concentr...

Systematic inflammatory response after spinal cord injury (SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI i...

This study investigated the effect of experimentally-induced cholestasis in the rat on the structure and function of the zona fasciculata, the glucocorticoid secretory region of the adrenal cortex. Wistar-Furth rats (200-250g) were assigned to three groups: bile duct ligated (BDL), Sham operated (Sham) and unmodified normal control (NC). On day 14, serum bilirubin and liver histology were perfo...