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تعداد نتایج: 11774 فیلتر نتایج به سال:
Progressive supranuclear palsy and Parkinson’s disease have distinct underlying neuropathology, but both diseases affect cognitive function in addition to causing a movement disorder. They impair response inhibition and may lead to impulsivity, which can occur even in the presence of profound akinesia and rigidity. The current study examined the mechanisms of cognitive impairments underlying di...
Efavirenz (EFV) is principally metabolized by CYP2B6 to 8-hydroxyefavirenz (8OH-EFV) and to a lesser extent by CYP2A6 to 7-hydroxyefavirenz (7OH-EFV). So far, most metabolite profile analyses have been restricted to 8OH-EFV, 7OH-EFV, andEFV-N-glucuronide, even though these metabolites represent a minor percentage of EFV metabolites present in vivo.We have performed a quantitative phase I and II...
in severity: ketoacidosis, lactic acidosis, acetic acidosis, and loss of bicarbonate in urine. AKA arises from a complicated interplay of the metabolic effects of alcohol in fasted, dehydrated alcoholics who abruptly stop their intake of ethanol. β-Hydroxybutyrate is the predominant ketoacid. Metabolism of ethanol to acetaldehyde is catalyzed by alcohol dehydrogenase in the liver and results in...
Instructions: Submit your solution by Thursday, February 11, 11:59pm, in the drop box labelled CS161 in 283 Soda Hall. Print your name, your class account name (e.g., cs161-xy), your TA's name, the discussion section time where you want to pick up your graded homework, and " HW1 " prominently on the first page. Staple all pages together. Your solutions must be legible and the solution to each p...
Cristen J Willer1,18, Serena Sanna1,2,18, Anne U Jackson1, Angelo Scuteri3,4, Lori L Bonnycastle5, Robert Clarke6, Simon C Heath7, Nicholas J Timpson8, Samer S Najjar3, Heather M Stringham1, James Strait3, William L Duren1, Andrea Maschio2, Fabio Busonero2, Antonella Mulas2, Giuseppe Albai2, Amy J Swift5, Mario A Morken5, Narisu Narisu5, Derrick Bennett6, Sarah Parish6, Haiqing Shen9, Pilar Gal...
In the 1960s, the thesis that dietary cholesterol contributes to blood cholesterol and heart disease risk was a rational conclusion based on the available science at that time. Fifty years later the research evidence no longer supports this hypothesis yet changing the dietary recommendation to limit dietary cholesterol has been a slow and at times contentious process. The preponderance of the c...
BACKGROUND Over the last decade, many changes have taken place in the UK, which have affected the training that doctors receive. AIM To assess doctors' views on quality and adequacy of postgraduate training. METHODS Questionnaires about training sent to UK-trained doctors who graduated between 1974 and 2012. RESULTS Among trainees towards the end of their first year of medical work and tr...
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