نتایج جستجو برای: 153sm177lu edtmp

تعداد نتایج: 131  

2010
Ali Bahrami-Samani Mohammad Ghannadi-Maragheh Amir Reza Jalilian Sedigheh Moradkhani

Introduction: Nowadays various bone pain palliative therapeutic agents have been developed for bone metastases. Among those, Sm-ethylenediamine tetramethylene phosphonic acid (Sm-EDTMP) is the major therapeutic agent which is widely used in the world. In this study, production, quality control and biodistribution studies of this therapeutic radiopharmaceutical have been presented and followed b...

2016
Christopher R. Heery Ravi A. Madan Mark N. Stein Walter M. Stadler Robert S. Di Paola Myrna Rauckhorst Seth M. Steinberg Jennifer L. Marté Clara C. Chen Italia Grenga Renee N. Donahue Caroline Jochems William L. Dahut Jeffrey Schlom James L. Gulley

PSA-TRICOM is a therapeutic vaccine in late stage clinical testing in metastatic castration-resistant prostate cancer (mCRPC). Samarium-153-ethylene diamine tetramethylene phosphonate (Sm-153-EDTMP; Quadramet®), a radiopharmaceutical, binds osteoblastic bone lesions and emits beta particles causing local tumor cell destruction. Preclinically, Sm-153-EDTMP alters tumor cell phenotype facilitatin...

2012
Gonca G. Bural James M. Mountz

One month later the patient received 4.22 GBq (114 mCi) 153Samarium-EDTMP for palliation of severe bone pain. Post treatment, whole body 153Samarium scan was also a “superscan” showing very similar osseous metastases pattern to the 99mTc-MDP bone scan. Anterior and posterior whole body images 24 hours after intravenous administration of 153Sm-EDTMP demonstrate diffuse osseous metastases in a ve...

Journal: :Journal of the South African Veterinary Association 1998
R J Milner I Dormehl W K Louw S Croft

Nine dogs with primary bone tumours were treated with Samarium-153-EDTMP (Sm-153-EDTMP). Conventional treatment protocols were precluded by the size of the dogs and the owners' refusal of limb amputation. All the tumours were of the appendicular skeleton; 4 were confirmed osteosarcomas. The other 5 tumours were radiologically suspect for osteosarcoma. Bone scans were performed on all dogs using...

2003
Peter M. Anderson

the effectiveness of an intervention against cancer cells compared to normal tissue. Although chemotherapy and radiation are common and effective treatment modalities for skeletal neoplasia (1), bone-seeking radioisotopes offer a new opportunity to provide additional benefit via specific targeting of the skeleton and/or bone-forming lesions (e.g. osteoblastic metastases in the skeleton, marrow,...

Journal: :Sao Paulo medical journal = Revista paulista de medicina 2004
Elba Cristina Sá de Camargo Etchebehere Carlos Araújo Cunha Pereira Neto Mariana Cunha Lopes de Lima Allan de Oliveira Santos Celso Darío Ramos Cleide Maria Silva Edwaldo Eduardo Camargo

CONTEXT More than 50% of patients with prostate, breast or lung cancer will develop painful bone metastases. The purpose of treating bone metastases is to relieve pain, reduce the use of steroids and to maintain motion. OBJECTIVE To evaluate the use of samarium-153-EDTMP (153Sm-EDTMP) for the treatment of bone pain secondary to metastases that is refractory to clinical management. TYPE OF S...

Journal: :Cancer 2010
David M Loeb Robert F Hobbs Amarachukwu Okoli Allen R Chen Steve Cho Senthamizhchelvan Srinivasan George Sgouros Ori Shokek Moody D Wharam Tammy Scott Cindy L Schwartz

BACKGROUND Samarium-153 ethylenediamine tetramethylene phosphoric acid (153Sm-EDTMP) is a radiopharmaceutical that has been used to treat osteosarcoma. The authors conducted a phase 2 study to test safety and response of high-risk osteosarcoma to tandem doses of 153Sm-EDTMP and to determine correlation between radiation delivered by low and high administered activities. METHODS Patients with ...

Journal: :Acta cirurgica brasileira 2009
Arthur Villarim Neto Maria Kadja Meneses Torres Açucena Kércia Regina Santos Gomes Pereira Amália Cínthia Meneses Rêgo Italo Medeiros Azevedo Mário Bernardo-Filho Aldo Cunha Medeiros

PURPOSE Many patients with metastatic bone disease have to use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of samarium-153-EDTMP in bones and other organs of rats. METHODS Wistar male rats were randomly allocated into 2 groups of 6 rats each. The DS (docetaxel/samarium) group rece...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009
Saadia Skalli Marie-Dominique Desruet Jean-Cyril Bourre Jean-Pierre Caravel Jean-Philippe Vuillez

One of the current therapeutic approaches in the treatment of osteoblastic bone metastases uses the affinity of Samarium ((153)Sm) ethylene-diamine-tetramethylene phosphonic acid (EDTMP) for bone areas of bone turnover. As Samarium EDTMP is a beta-emitter, the radiotherapy contributes to osteoblastic bone lesion control over time. To date, the safety and effectiveness of Samarium therapy have n...

Journal: :iranian journal of nuclear medicine 2009
ali bahrami-samani mohammad ghannadi-maragheh amir reza jalilian simindokht shirvani-arani moein meftahi

introduction: nowadays various bone pain palliative therapeutic agents have been developed for bone metastases. among those, 153sm-ethylenediamine tetramethylene phosphonic acid (153sm-edtmp) is the major therapeutic agent which is widely used in the world. in this study, production, quality control and biodistribution studies of this therapeutic radiopharmaceutical have been presented and foll...

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