1 Arak Üniversitesi Tıp Fakültesi, Moleküler Tıp Araştırma Merkezi, Arak, İran 2 Epidemiyoloji ve Mikrobiyoloji Araştırma Enstitüsü, Minsk, Beyaz Rusya, 3 Beyaz Rusya Pulmonoloji ve Fitizyoloji Araştırma Enstitüsü, Minsk, Beyaz Rusya, 4 Shahid Beheshti Üniversitesi Tıp Fakültesi, Masih Daneshvari Hastanesi, Mikobakteriyoloji Araştırma Merkezi (MAM), Tahran, İran 5 Shahed Üniversitesi Tıp Fakült...

We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its transesterification in the presence of ethanol with special emphasis on the risks of drug-drug interaction. The hydrolysis of CDP323 was evaluated in vitro using human liver and intestinal microsomes and recombinant human carboxylesterases (hCES1 and 2) and was shown to ...

This study characterized the kinetics, variability, and factors that affect UDP–glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the highand low-affinity components differed by more than an order of magnitude (13 6 6 vs. 374 6 175 mM), but were comparable in terms of the maximal...

Numerous plant species are considered weeds in agronomic cropping systems. Weeds have many attributes undesirable to crop producers, not the least being the ability to reduce crop yields through competition for resources such as sunlight, water, nutrients, and space. Weeds also may harbor insects and provide a host for certain plant pathogens. Some weed species, such as wild garlic and eastern ...

Pär Larsson1, Petra C F Oyston2, Patrick Chain3, May C Chu4, Melanie Duffield2, Hans-Henrik Fuxelius5, Emilio Garcia3, Greger Hälltorp5, Daniel Johansson1, Karen E Isherwood2, Peter D Karp6, Eva Larsson1, Ying Liu7, Stephen Michell2, Joann Prior2, Richard Prior2, Stephanie Malfatti3, Anders Sjöstedt8, Kerstin Svensson1, Nick Thompson9, Lisa Vergez3, Jonathan K Wagg6, Brendan W Wren10, Luther E ...

Genetic susceptibility testing for common complex disease is a practice that is currently in clinical use. There are two types of gene mutations, and therefore, two varieties of genotype testing: deterministic and susceptibility. As the term suggests, deterministic genes determine whether or not a person will develop a given trait in Mendelian fashion, such as Huntington’s disease. Genotype scr...

Purpose: In the Noise Outcomes in Servicemembers Epidemiology Study, Veterans recently separated from the military undergo comprehensive assessments to initiate longterm monitoring of their auditory function. We developed the Tinnitus Screener, a four-item algorithmic instrument that determines whether tinnitus is present and, if so, whether it is constant or intermittent, or whether only tempo...

Unsaturated fatty acids are ligands of PPAR-g , which up-regulates genes involved in fatty acid transport and TAG synthesis and the insulin-sensitising adipokine adiponectin, which activates fatty acid b-oxidation via PPAR-a action in liver. We investigated the effect of dietary fatty acid interaction with PPARG, PPARA and ADIPOQ gene variants on plasma lipid and adiponectin concentrations in t...

Nika N Danial1–3, Loren D Walensky2–5, Chen-Yu Zhang6, Cheol Soo Choi7,8, Jill K Fisher1–3, Anthony J A Molina9, Sandeep Robert Datta10,13, Kenneth L Pitter2–5, Gregory H Bird2–5, Jakob D Wikstrom9, Jude T Deeney11, Kirsten Robertson1–3, Joel Morash2–5, Ameya Kulkarni7,8, Susanne Neschen7,8, Sheene Kim7,8, Michael E Greenberg10, Barbara E Corkey11, Orian S Shirihai9, Gerald I Shulman7,8, Bradfo...