The purpose of our study was to examine whether cyclooxygenase and lipoxygenase inhibitors ameliorate delayed neuronal death in the hippocampal CA1 sector in Mongolian gerbils after 5 minutes of forebrain ischemia. Gerbils were injected intraperitoneally with cyclooxygenase inhibitors piroxicam and flurbiprofen or with lipoxygenase inhibitors AA-861 and BW-755C. Seven days after ischemic insult...

To elucidate the role of focal adhesion kinase (pp125FAK) in transformation, its phosphorylation in transformed fibroblasts was compared with that of detransformed fibroblasts induced by a histone deacetylase inhibitor, trichostatin A (TSA). Inhibition of histone deacetylase activity in two different ras-transformed fibroblast lines by TSA induced a morphological change into a flattened and mor...

BACKGROUND Oxidative stress is a component of many pathological conditions including neurodegenerative diseases and inflammation. An important source of reactive oxygen species (ROS) are lipoxygenases (LOX) - enzymes responsible for the metabolism of arachidonic acid and other polyunsaturated fatty acids. LOX inhibitors have a protective effect in inflammatory diseases and in neurodegenerative ...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,279 5.3 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,193 5.0 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,114 4.7 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2,453 10.3 20 to 24 years . . . . . . . . . . . . . . . . ...

AIM To improve the drug concentration in liver metastases, docetaxel was encapsulated in polyethyleneglycol-liposomes and administered regionally with degradable starch microspheres (DSM). MATERIALS AND METHODS A rodent model of solitary metastasis (CC-531 adenocarcinoma) was studied. The animals were randomized into six groups and treated with 15 ng/kg docetaxel: I: intravenous (i.v.). II: P...

The effect of a selective thromboxane synthetase inhibitor, OKY-046, and a selective 5-lipoxygenase inhibitor, AA-861, on bronchial responsiveness to acetylcholine was studied in 23 asthmatic subjects. The provocative concentration of acetylcholine producing a 20% fall in forced expiratory volume in one second (PC20 FEV1) was measured before and after oral administration of OKY-046 (3000 mg ove...

, 861 (2009); 326 Science et al. Assaf Vardi, Cell Death in Marine Phytoplankton Viral Glycosphingolipids Induce Lytic Infection and www.sciencemag.org (this information is current as of November 5, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/326/5954/861 version of this article at: including high-resolution figures,...

, 861 (2009); 326 Science et al. Assaf Vardi, Cell Death in Marine Phytoplankton Viral Glycosphingolipids Induce Lytic Infection and www.sciencemag.org (this information is current as of November 5, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/326/5954/861 version of this article at: including high-resolution figures,...

conclusions fever phobia remains common, not only among low socioeconomic status mothers but also among those of high socioeconomic status. healthcare providers should take fever phobia into account and provide correct information to caregivers about fever at all visits. patients and methods a questionnaire was use to explore the attitudes, knowledge, and practices of mothers of 861 children br...

An initial increase (3-12 hr) in the polymorphonuclear leukocytes (PMN) counts after ligation of the rat left main coronary artery was reduced by 49.4% (at 12 hr) by a 5-lipoxygenase inhibitor, AA-861 (80 mg/kg, p.o., 1 hr before ligation). Depletion of the complement components induced by cobra venoma factor (CVF) (i.v.), given one day before, resulted in significant reduction in the PMN accum...