response to SO 20881 in hypertension. N Eng J Med 297: 184-188, 1977 25. Davis JO, Freeman RH, Johnson JA, Spielman NS: Agents which block the action of the renin-angiotensin system. Circ Res 34: 279285.1974 26. Watkins BE, Davis JO, Freeman RH, Stephens GA, DeForrest JM: Effects of the oral converting enzyme inhibitor (SO 14225) on renovascular hypertension in the dog. Proc Soc Exp Biol Med 15...

A 43 kDa phospholipase C-activating protein has been purified previously from turkey erythrocytes and shown to express immunological properties expected of that of the Gq family of G-protein a-subunits [Waldo, Boyer, Morris and Harden (1991) J. Biol. Chem. 266, 14217-14225]. Internal amino acid sequence has now been obtained from this protein which shares 50-100% sequence identity with sequence...

1. The effect of aprotinin-induced blockade of the kallikrein-kinin system on haemodynamic and biochemical responses to converting enzyme inhibition by SQ 14 225 was evaluated in 26 patients with essential hypertension. 2. SQ 14 225 lowered blood pressure in high, normal and low renin hypertension. In low and normal renin patients, but not in high renin patients, the acute blood pressure-loweri...

The role of ANG II, a potent dipsogenic hormone, in copious drinking of seawater eels was examined. SQ-14225 (SQ), an angiotensin-converting enzyme inhibitor, infused intra-arterially at 0.01-1 microgram. kg(-1). min(-1), depressed drinking and arterial blood pressure in a dose-dependent manner. The inhibition was accompanied by a small decrease in plasma ANG II concentration, which became sign...