Prosaposin is both a precursor of sphingolipid activator proteins and a secreted neurotrophic and myelinotrophic factor. Because peripheral nerve regeneration is impaired in diabetes mellitus, we measured prosaposin protein levels from control and streptozotocindiabetic rats by collecting endoneurial fluid secreted into a bridging tube connecting the ends of transected sciatic nerve. Prosaposin...

A key goal of biomedical research is to elucidate the complex network of gene interactions underlying complex traits such as common human diseases. Here we detail a multistep procedure for identifying potential key drivers of complex traits that integrates DNA-variation and gene-expression data with other complex trait data in segregating mouse populations. Ordering gene expression traits relat...

Vernalization is the process by which sensing a prolonged exposure to winter cold leads to competence to flower in the spring. In winter annual Arabidopsis thaliana accessions, flowering is suppressed in the fall by expression of the potent floral repressor FLOWERING LOCUS C (FLC)1. Vernalization promotes flowering via epigenetic repression of FLC2. Repression is accompanied by a series of hist...

Odisha state is highly endemic for malaria and among several Anopheline species found in the state, Anopheles subpictus is known to be one of the most prevalent species. An. subpictus complex consists of four sibling species i,e A,B,C and D. However, no work has been conducted on prevalence of sibling species of An. subpictus in Odisha. Hence attempt was made to study the prevalence of sibling ...

Diabetic retinopathy is characterized by progressive vision loss and the advancement of retinal micoraneurysms, edema and angiogenesis. Unfortunately, managing glycemia or targeting vascular complications with anti-vascular endothelial growth factor agents has shown only limited efficacy in treating the deterioration of vision in diabetic retinopathy. In light of growing evidence that mitochond...

D-004, a lipid extract from royal palm (Roystonea regia) fruits, has shown to inhibit prostate 5-α-reductase in vitro, and to prevent prostate hyperplasia (PH) induced with T, not with DHT, in rodents, but its potential estrogenic or antiestrogenic effects had not been studied yet. This study investigated whether D-004 produces estrogenic or antiestrogenic effects, as assessed in the uterotroph...

PURPOSE VX-710 (biricodar, Incel) restores drug sensitivity to P-glycoprotein (MDR1) and multidrug resistance-associated protein (MRP1)-expressing cells. This Phase II study evaluated the safety/tolerability, pharmacokinetics, and efficacy of VX-710 plus paclitaxel in women with locally advanced or metastatic breast cancer who were refractory to prior paclitaxel therapy. EXPERIMENTAL DESIGN E...

set an appropriate drug dosing schedule to take into account of their altered drug disposition kinetics. However, little work has been done to estimate the decrease of total clearance (CLtot) in relation to the degree of residual hepatic function. Therefore, there is great need for a suitable marker to quantitatively predict the hepatic metabolic capacity in patients with hepatic failure. In hu...