The IMS Open Corpus Workbench (CWB) software currently uses a simple tabular data model with proven limitations. We outline and justify the need for a new data model to underlie the next major version of CWB. This data model, dubbed Ziggurat, defines a series of types of data layer to represent different structures and relations within an annotated corpus; each such layer may contain variables ...

BACKGROUND Familial hypertrophic cardiomyopathy (FHC) is characterized by genetic and clinical heterogeneity. Five percent of FHC families have 2 FHC-causing mutations, which results in earlier disease onset, increased cardiac dysfunction, and a higher incidence of sudden death events. These observations suggest a relationship between the number of gene mutations and phenotype severity in FHC. ...

BACKGROUND Nomophobia, which is a neologism derived from the combination of "no mobile," "phone," and "phobia" is considered to be a modern situational phobia and indicates a fear of feeling disconnected. OBJECTIVE No psychometric scales are available in Italian for investigating such a construct. We therefore planned a translation and validation study of the Nomophobia Questionnaire (NMP-Q),...

Stainlesssteel 403 is high-alloysteelwith good corrosion resistance and it’svery hard material. Abrasive water jet is an effective method for machining, cutting and drilling of stainlesssteel 403. In thispaperweoptimize the metalremoval rate of stainlesssteel 403 in abrasive water jet machining. The MRRisoptimize by usingthreeparameters water pressure, abrasive flow rate and stand-off distance ...

Nociceptin/orphanin FQ (N/OFQ) regulates several biological functions via selective activation of the N/OFQ receptor (NOP), a member of the opioid receptor family. We recently identified a new high affinity and highly selective NOP agonist AT-403. In this study, we characterized the functional profile of AT-403 and compared it to other known nonpeptide NOP agonists Ro 65-6570, Ro 2q, SCH-221510...

The chemokine receptor CCR5 polymorphism, which confers resistance to HIV infection, has been associated with reduced risk of cardiovascular disease. However, the association of the chemokine, CCL5, and its receptor, CCR5, polymorphism and coronary artery disease (CAD) in the Taiwanese has not been studied. In this study, 483 subjects who received elective coronary angiography were recruited fr...

A large fraction of the trace metal pool in estuarine and coastal waters is complexed with colloidal-sized macromolecular organic matter. Bioaccumulation and bioavailability studies of trace metals have generally utilized freeionic dissolved metal ions. Consequently, little is known about the uptake and depuration kinetics of the colloidally bound species. Chemical characteristics such as the r...

OBJECTIVE Sesamol, a phenolic component of lignans, has been previously shown to reduce lipopolysaccharide-induced oxidative stress and upregulate phosphatidylinositol 3-kinase/Akt/endothelial nitric oxide synthase pathways. In the present study, we synthesized a modified form of sesamol (INV-403) to enhance its properties and assessed its effects on atherosclerosis. METHODS AND RESULTS Watan...

Abstract Background Sexually transmitted infections (STIs) such as Human Immunodeficiency Virus (HIV), Hepatitis B (HBV), C (HCV), and Syphilis have continued a significant public health problem, especially in areas with substandard infection prevention control programs. It is known that STIs are largely associated the increased occurrence of cervical cancer. To date, little about burden among ...