Type 2 antigens such as polyvinylpyrrolidone (PVP), 1 type III pneumococcal polysaccharide ($3), and dinitrophenyl (DNP)-ficoll characteristically elicit antibody responses in mice that consist almost entirely of antibodies of the IgM and IgG3 isotypes (1-4). Type 2 antigens also are generally unable to prime mice to produce I gG 1 and IgG2 antibodies after secondary challenge, i.e. they are un...

Dopamine D(2) receptor occupancy of antipsychotic drugs is calculated relative to the subject's D(2) receptor binding potential (BP) in the drug-free state (baseline BP). Because baseline BP is seldom known in patients with schizophrenia, population means from unrelated control samples are often used to estimate it. However, this is likely to introduce bias and error into the occupancy measure....