1 Department of Cell Biology, University Medical Centre Groningen, University of Groningen, 9713 AV Groningen, The Netherlands 2 Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands 3 Wellcome Trust Medical Research Council Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Madin...

at least among some urban populations.7 A third hypothesis is based on the stages of an adolescent’s acquisition of lesbian or bisexual identity. “Heterosexual immersion” may be one strategy for responding to the identity confusion stage of development: “Some adolescents establish heterosexual involvements in hopes of ‘curing’ themselves of their homosexual interests....In some cases, an adoles...

A general introduction to artificial intelligence methods of measurement signal processing is given in Article 128, Nature and Scope of AI Techniques, Volume 2. In nature, evolution is mostly determined by natural selection or different individuals competing for resources in the environment. Those individuals that are better are more likely to survive and propagate their genetic material. The e...

Data and Methods The study uses data from the 1991 followup of the National Survey of Adolescent Males (NSAM), a nationally representative survey of never-married, noninstitutionalized males aged 15–19. The original wave of face-to-face interviews conducted in 1988 had a response rate of 74%. In the 1991 wave, face-to-face interviews were conducted with 1,676 respondents aged 17–22, for an 89% ...

Several critical lipid intermediates, such as DAG and ceramide, can be toxic when they accumulate in cellular membranes. This is not only because they affect membrane structure and organization but also because they are potent signaling molecules. Numerous studies have linked elevated ceramides with cellular stress, cell cycle arrest, apoptosis, and insulin resistance; ceramide accumulation is ...

When I(131)-albumin is given intravenously to rabbits, the radioactive breakdown products that are released into the plasma and urine can be extracted into acetone. Paper chromatography and paper electrophoresis show that about 80 per cent of these are I(131)-iodide and the remainder are organic I(131)-iodine compounds. When I(131)-iodide is given to rabbits taking iodide in their drinking wate...

PURPOSE The objective of this study was to determine the feasibility of exploiting the overexpression of somatostatin subtype-2 receptors (sstr(2)) on human medulloblastoma cells to develop targeted radiodiagnostics and radiotherapeutics for this disease. EXPERIMENTAL DESIGN The following radioiodinated peptides were prepared using chloramine-T and evaluated: [(131)I-Tyr(3)]octreotide ([(131)...

[F]DPA-714 [N,N-diethyl-2-(2-(4-(2[F]-fluoroethoxy)phenyl) 5,7dimethylpyrazolo[1,5a]pyrimidin-3-yl)acetamide] is a new radioligand currently used for imaging the 18-kDa translocator protein in animal models of neuroinflammation and recently in humans. The biodistribution by positron emission tomography (PET) in baboons and the in vitro and in vivo metabolism of [F]DPA-714 were investigated in r...