Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significant factor in cancer pathophysiology. In this study, we investigated the little known alternative splice isoform survivin-3B (S-3B) that is overexpressed in a tumor-specific manner. Ectopic overexpression of S-3B drove tumorigenesis by facilitating immune escape in a manner associated with resistance ...

ADVERTISEMENT RETURN TO ISSUEIn This IssueNEXTIn Issue, Volume 13, Issue 11Jennifer E. GoldenJennifer GoldenMore by Jennifer Goldenhttps://orcid.org/0000-0002-6813-3710Cite this: ACS Med. Chem. Lett. 2022, 11, 1686–1687Publication Date (Web):November 10, 2022Publication History Received19 October 2022Published online10 November inissue 10 2022https://doi.org/10.1021/acsmedchemlett.2c00451Copyri...

Carriers of balanced reciprocal translocations may have a (high) risk for producing liveborn children with an unbalanced karyotype. We report a large family in which a translocation between the long arm of chromosome 11 and the short arm of chromosome 13 is segregating in at least five generations. During the course of our study 15 carriers of the balanced translocation were identified and nine...

background: in cancers of prostate, breast, oropharynx, lung, hypopharynx and skin, human tissue kallikreins has been demonstrated as a main role in these problems. there are many research works in which some human tissue kallikreins are expressed in salivary glands. in the present study, the main goal was to determine expression of human tissue kallikreins 4, 8, 10, 11 and 13 in pleomorphic ad...