velopment and progression of cerebroand cardiovascular disorders. The pathogenesis of hypertension is accompanied with the increased oxygen free radical production, the decreased nitric oxide bioavailability in the vasculature and reactive oxygen species-mediated cardiovascular remodeling. Hypertensive patients show increased levels of plasma superoxide, hydrogen peroxide and lipid peroxide. In...

Neuropsychiatric (NP) manifestations pose diagnostic and therapeutic challenges in systemic lupus erythematosus (SLE). Less than one-third of these events can be directly attributed to SLE; accordingly attribution to SLE remains a considerable challenge. Increased generalized SLE disease activity or damage, previous or concurrent major neuropsychiatric SLE (NPSLE) events, and persistently posit...

Commentary on Tawar, R.G.; Duquerroy, S.; Vonrhein, C.; Varela, P.F.; Damier-Piolle, L.; Castagné, N.; MacLellan, K.; Bedouelle, H.; Bricogne, G.; Bhella, D.; Eléouët, J.-F.; Rey, F.A. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science2009, 326, 1279-1283.