among the most widely prescribed drugs worldwide for the treatment of inflammation, pain, and fever. However, the use of those drugs is often limited by numerous side effects, particularly in the gastrointestinal tract and the kidney. The inflammatory action of NSAIDs is attributed to the inhibition of cyclooxygenase (COX), and consequently, the conversion of arachidonic acid into prostaglandin...

L’ouvrage d’Alexandre Delin est la version remaniee d’une these preparee a l’universite de Paris I – Pantheon-Sorbonne sous direction Jean-Philippe Genet et soutenue en 2013. L’histoire des universites medievales anglaises et, specialement plus importante, celle d’Oxford, depuis longtemps fourni matiere tres abondantes editions sources etudes diverses langue anglaise, mais pratiquement aucune f...

Basal forebrain cholinergic neurons (BFCN) are selectively vulnerable to damage and loss in a number of neurodegenerative disorders that afflict the elderly, particularly Alzheimer's disease. The reasons for this selective vulnerability remain poorly understood. Given that intraneuronal accumulation of the amyloid-β peptide (Aβ) has been shown to exert deleterious effects on neurons, we tested ...

1282-1328 yılları arasında Bizans İmparatorluğu tahtında bulunan II. Andronikos Paleologos dönemi pek çok önemli meselenin yaşandığı bir süreçtir. Uzun yıllar devam eden iç savaş, artan vergiler ve düşman saldırılarına maruz kalan halkın devletle olan bağı zayıflamıştır. Kiliselerin birliği konusunda atılan adımların hem ruhban sınıfında de halkta yarattığı hoşnutsuzluk ile ilgilenmek durumunda...

3. Lualdi JC, Goldhaber SZ. Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection, and therapeutic implications. Am Heart J. 1995;130:1276-1282. 4. Kasper W, Konstantinides S, Geibel A, Tiede N, Krause T, Just H. Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary e...