Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC(50)  ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.

Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis(quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2-propanol. The assay for the in vitro toxicity of water-soluble tetraoxanes 5a-5d to malaria parasites i...

Unsymmetrical dispiro- and spirotetraoxanes have been designed and synthesized via acid-catalyzed cyclocondensation of bis(hydroperoxides) with ketones. Incorporation of water-soluble and polar functionalities, via reductive amination and amide bond formation, produces several analogues with low nanomolar in vitro antimalarial activity. Several analogues display an unprecedented level of oral a...

Phytoestrogens and Cardiovascular Disease : Where's the Meat? Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2002 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000027188.24963.EA 2002;22:1245-1247 Arterioscler Thromb ...

Craig ANDERSON, Trevor MACKLIN BAE SYSTEMS Advanced Technology Centres, Great Baddow, Chelmsford, Essex CM2 8HN, UK Tel. +44 (0) 1245 242654, Fax +44 (0) 1245 475244, email [email protected] Christine GOMMENGINGER, Meric SROKOSZ Southampton Oceanography Centre, Empress Dock, Southampton, Hants SO14 3ZH, UK Tel. +44 (0) 2380 596414, Fax +44 (0) 2380 596400, email [email protected]....

In the title mol-ecule, C16H13N5, the plane of the tetra-zole ring forms dihedral angles of 16.37 (7) and 76.59 (7)° with the two phenyl rings. The dihedral angle between the phenyl rings is 68.05 (6)°. The pyrimidine ring is in a flattened boat conformation. In the crystal, mol-ecules are linked by pairs of N-H⋯N hydrogen bonds, forming inversion dimers.

The title compound, nona-niobium vanadium penta-cosa-oxide, was prepared by a solid-state reaction at 1198 K. It is isotypic with Nb9AsO25, Nb9PO25 and Ta9VO25. The structure consists of NbO6 octa-hedra (one with 4/m.. and two with m.. symmetry) and VO4 tetra-hedra (-4.. symmetry) sharing corners and edges to form a three-dimensional framework. This framework can be considered as a junction bet...

BACKGROUND NKG2D is an activating receptor expressed by natural killer and T cells, which have crucial functions in tumor and microbial immunosurveillance. Several cytokines have been identified as modulators of NKG2D receptor expression. However, little is known about NKG2D gene regulation. In this study, we found that microRNA 1245 attenuated the expression of NKG2D in natural killer cells. ...