Human PrP (huPrP) is a high-affinity receptor for oligomeric amyloid β (Aβ) protein aggregates. Binding of Aβ oligomers to membrane-anchored huPrP has been suggested trigger neurotoxic cell signaling in Alzheimer’s disease, while an N-terminal soluble fragment can sequester and reduce their toxicity. Synthetic species are known be heterogeneous, dynamic, transient, rendering structural investig...

•Numerous SARS-CoV-2 proteins synergize to suppress immune sensing and signaling•Nsp14 targets IFNAR1 for lysosomal degradation•ORF3a ORF7a block autophagy by different mechanisms•Synergistic treatment with IFN-γ -λ1 is highly effective against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate responses but may still be vulnerable some. Here, we systematically anal...